Pup-On-target for Small molecule Target Identification Technology, POST-IT, is a revolutionary tool for accurately identifying protein targets of bioactive molecules in living cells and organisms, successfully identifying SEPHS2 and VPS37C as targets for dasatinib and hydroxychloroquine, respectively.

MDGAs are highly diffusive molecules that alter both neuroligin-1 and AMPA receptor dynamics and function, thereby significantly delaying the differentiation of excitatory post-synapses.

A statistical method for summarizing single-cell gene expression data identifies normal and disease-specific transcriptional programs from an atlas of 57,600 cells.

Non-canonical ‘testis-specific’ actin-related protein (Arp), Arp53D, is critical for early embryonic development in Drosophila, revealing important roles for lineage-specific, divergent, testis-expressed non-canonical Arps outside the male germline in animals.

A new Cereblon-recruiting bifunctional tau ligand, QC-01-175, promotes aberrant tau degradation and rescue of stress vulnerability in human neuronal cell models of tauopathy.

Cellular and chemogenetic approaches identify a novel mode of chemotransduction involving regulation of basal breathing by CO₂/H+-dependent disinhibition.

Specific inhibition of cyclin-dependent kinase-like 5 (CDKL5), a kinase linked to a severe neurodevelopmental disorder, demonstrates an important role in the regulation of excitatory hippocampal synapses and synaptic plasticity that was not previously appreciated in rodent knock-out models.

The proper mechanical stimulus could promote the migration of Prrx1⁺ cells to the injury site to enhance enthesis injury repair.

The Platynereis startle circuit links polycystin-dependent hydrodynamic sensors to muscle and ciliary effector cells.