2,975 results found
    1. Developmental Biology
    2. Genetics and Genomics

    Paths and pathways that generate cell-type heterogeneity and developmental progression in hematopoiesis

    Juliet R Girard, Lauren M Goins ... Utpal Banerjee
    A combination of mRNA sequencing and genetic analysis reveals mechanisms that govern the development of distinct differentiated blood cell types from hematopoietic progenitors.
    1. Developmental Biology
    2. Physics of Living Systems

    Cost-precision trade-off relation determines the optimal morphogen gradient for accurate biological pattern formation

    Yonghyun Song, Changbong Hyeon
    The morphogen profiles that pattern the fruit fly attain desired levels of spatial precision in a cost-effective manner.
    1. Chromosomes and Gene Expression

    Stem-loop and circle-loop TADs generated by directional pairing of boundary elements have distinct physical and regulatory properties

    Wenfan Ke, Miki Fujioka ... James B Jaynes
    Boundary:boundary pairing generates either stem-loop or circle-loop TADs, and these loop topologies differ in how they impact chromosome structure and genetic activities.
    1. Neuroscience

    A double dissociation between semantic and spatial cognition in visual to default network pathways

    Tirso RJ Gonzalez Alam, Katya Krieger-Redwood ... Elizabeth Jefferies
    Default mode network and visual cortex are connected via two parallel pathways that differentially respond to the processing of visual scenes and semantic information about objects, reflecting domain-specific organisation.
    1. Cancer Biology
    2. Cell Biology

    EHMT2 methyltransferase governs cell identity in the lung and is required for KRAS G12D tumor development and propagation

    Ariel Pribluda, Anneleen Daemen ... Melissa R Junttila
    G9a regulates chromatin-bound b-catenin enabling cell-intrinsic control of WNT signaling-mediated cell fate decisions.
    1. Neuroscience

    Cross-frequency synchronization connects networks of fast and slow oscillations during visual working memory maintenance

    Felix Siebenhühner, Sheng H Wang ... Satu Palva
    Cross-frequency synchronization of neuronal oscillations in visual and attentional brain systems predicts human working memory performance.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Genetic basis and dual adaptive role of floral pigmentation in sunflowers

    Marco Todesco, Natalia Bercovich ... Loren H Rieseberg
    Variation in patterns of floral UV pigmentation is controlled by a single transcription factor in sunflower and affects both pollinator attraction and responses to environmental stresses.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Single-cell analysis of mosquito hemocytes identifies signatures of immune cell subtypes and cell differentiation

    Hyeogsun Kwon, Mubasher Mohammed ... Ryan C Smith
    Single-cell RNA-seq analysis reveals an increased complexity of mosquito hemocytes, enabling the functional and molecular characterization of immune cell sub-populations in Anopheles gambiae.
    1. Developmental Biology
    2. Neuroscience

    Mechanisms underlying microglial colonization of developing neural retina in zebrafish

    Nishtha Ranawat, Ichiro Masai
    Genetic and imaging analysis reveal that microglial precursors use ocular blood vessels as a pathway to enter the optic cup and subsequently infiltrate the retina preferentially through the neurogenic region.
    1. Neuroscience

    Cognitive regulation alters social and dietary choice by changing attribute representations in domain-general and domain-specific brain circuits

    Anita Tusche, Cendri A Hutcherson
    Regulatory success operates by goal-consistent increases and decreases of distinct attribute representations in generic neural hubs and in domain-specific brain regions, explaining when and why regulatory success generalizes across domains and contexts.

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