Browse the search results

Page 2 of 257
    1. Cell Biology

    Single-cell RNA-seq reveals hidden transcriptional variation in malaria parasites

    Adam J Reid et al.
    Plasmodium parasite transcription shifts dramatically along asexual development, and transmission stages variably express important immune evasion genes, suggesting much interesting biology has until now been hidden by bulk analyses.
    1. Chromosomes and Gene Expression

    Transcription-coupled genetic instability marks acute lymphoblastic leukemia structural variation hotspots

    Merja Heinäniemi et al.
    Convergent transcription and stalling of transcription are enriched at DNA breakpoints found in acute lymphoblastic leukemia and associate with DNA structures and sequences that mediate genetic instability.
    1. Genetics and Genomics

    Neuronal TORC1 modulates longevity via AMPK and cell nonautonomous regulation of mitochondrial dynamics in C. elegans

    Yue Zhang et al.
    Modulating the nutrient sensor TORC1 only in neurons in C. elegans is sufficient to regulate systemic longevity via inter-tissue signals that remodel mitochondria networks in non neuronal cells.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Defining the location of promoter-associated R-loops at near-nucleotide resolution using bisDRIP-seq

    Jason G Dumelie, Samie R Jaffrey
    Genome-wide profiling of R-loops at near single-nucleotide resolution reveals distinct R-loop boundaries depending on the presence and location of the first exon-intron junction.
    1. Neuroscience

    Peptidoglycan-dependent NF-κB activation in a small subset of brain octopaminergic neurons controls female oviposition

    Ambra Masuzzo et al.
    The universal bacteria cell wall component peptidoglycan impacts the egg-laying behavior of infected Drosophila females by directly modulating the activity of few brain octopaminergic neurons.
    1. Ecology
    2. Plant Biology

    Plant defense phenotypes determine the consequences of volatile emission for individuals and neighbors

    Meredith C Schuman et al.
    Both the frequency of sesquiterpene-emitting individuals and the defense capacity of individual plants determine the consequences of sesquiterpene volatile emission for individuals and their neighbors in populations of the wild tobacco Nicotiana attenuata.
    1. Cancer Biology
    2. Computational and Systems Biology

    Mitochondrial respiratory gene expression is suppressed in many cancers

    Ed Reznik et al.
    Building on previous work (Reznik et al., 2016), independent measurements of mitochondrial genome copy number and expression indicate that several solid tumor types suppress respiratory metabolism compared to normal tissue.
    1. Neuroscience

    Control of feeding by Piezo-mediated gut mechanosensation in Drosophila

    Soohong Min et al.
    Gut-innervating sensory neurons detect large food volumes and inhibit feeding in Drosophila through the mechanically gated ion channel Piezo.
    1. Cell Biology

    The quantitative architecture of centromeric chromatin

    Dani L Bodor et al.
    The number of CENP-A molecules at human centromeres helps to explain how this structure is built and epigenetically inherited.
    1. Neuroscience

    In vivo imaging with a water immersion objective affects brain temperature, blood flow and oxygenation

    Morgane Roche et al.
    Brain temperature and oxygenation vary according to the imaging conditions during two-photon microscopy.