93 results found
    1. Biochemistry and Chemical Biology
    2. Physics of Living Systems

    Mechanically transduced immunosorbent assay to measure protein-protein interactions

    Christopher J Petell, Kathyrn Randene ... Joshua P Steimel
    METRIS is a method that reports a mechanical readout of protein-protein interactions and due to its unique properties, it will allow many protein-protein interactions to be quantitatively measured easily that are currently laborious to measure with conventional methods.
    1. Biochemistry and Chemical Biology

    A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion

    Xiao-Chuan Cai, Tuo Zhang ... Minkui Luo
    A chemical probe was characterized for potency, selectivity, and ability to alter CARM1-dependent epigenetic plasticity against cancer cell invasion.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Single-cell analysis of the aged ovarian immune system reveals a shift towards adaptive immunity and attenuated cell function

    Tal Ben Yaakov, Tanya Wasserman ... Yonatan Savir
    The ovarian immune system ages while coping with the two main challenges of the aging ovary before menopause, the inflammatory stimulations due to repeated cycles and the increasing need for clearance of accumulating atretic follicles.
    1. Evolutionary Biology
    2. Physics of Living Systems

    Environmental heterogeneity can tip the population genetics of range expansions

    Matti Gralka, Oskar Hallatschek
    Environmental heterogeneity can dramatically reduce the efficacy of selection and alter the neutral evolutionary dynamics in microbial range expansions.
    1. Genetics and Genomics
    2. Neuroscience

    Reorganization of postmitotic neuronal chromatin accessibility for maturation of serotonergic identity

    Xinrui L Zhang, William C Spencer ... Evan S Deneris
    Terminal selectors reorganize postmitotic neuronal chromatin to select cis-regulatory elements during 5-HT neuron maturation.
    1. Developmental Biology

    Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features

    Dominic WH Shayler, Kevin Stachelek ... David Cobrinik
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Microbiology and Infectious Disease

    Resolving the origins of secretory products and anthelmintic responses in a human parasitic nematode at single-cell resolution

    Clair R Henthorn, Paul M Airs ... Mostafa Zamanian
    A single-cell gene expression atlas in a human parasitic nematode provides new insights into the distribution of anthelmintic targets and the origins of secretory molecules with diagnostic and therapeutic potential at the host–parasite interface.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS

    Mary McMahon, Adrian Contreras ... Davide Ruggero
    Cancer-associated changes in small nucleolar RNAs and site-specific pseudouridine modifications impact ribosome activity.
    1. Ecology

    Full factorial construction of synthetic microbial communities

    Juan Diaz-Colunga, Pablo Catalan ... Alvaro Sanchez
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Cell Biology
    2. Neuroscience

    C9orf72 arginine-rich dipeptide repeat proteins disrupt karyopherin-mediated nuclear import

    Lindsey R Hayes, Lauren Duan ... Jeffrey D Rothstein
    Poly-PR and poly-GR interact with importin β, disrupt importin-cargo loading, and inhibit nuclear import in permeabilized cells in a manner that can be rescued by RNA.

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