High-throughput droplet-based cultivation of gut microbes reduces biases of traditional cultivation strategies and thereby enables detection of difficult-to-culture organisms, which is required in applications such as antibiotic screening.

New open-source method contains all the tools for extracting open chromatin or RNA from thousands of single cells in parallel for <5% of the cost of state-of-the-art commercial alternatives, paving the way for whole-tissue atlasing and new protocol development.

A droplet microfluidics approach to stably trap and phenotype individual micron-sized algae reveals their distinct but stereotyped movement patterns and how they respond in real time to local environmental cues, including novel boundary circling behaviour under strong confinement.

The amphipathic helix of perilipin 4 relies on the organization of its polar residues to form a remarkably immobile and stable protein layer on the surface of lipid droplets.

Microfluidics and dynamic imaging allow systematic characterization of polarization kinetics in B lymphocytes and highlight the role of microtubules as master regulators of actin polymerization at the immune synapse.

A new high-throughput method for single-cell RNA-seq in yeast cells shows how stochastic expression of glucose-repressed genes contributes to cell-to-cell differences during adaptation to an environmental change.

Tissue infection by an extracellular pathogen is recapitulated by encasing a bacterial colony within a droplet gel to allow immune cell attack, driving spatially-controlled microbial social behavior.

This microscale cultivation strategy will help in the discovery of novel bacterial species and their prioritization for antibiotic screening campaigns.

The targeting of proteins from the endoplasmic reticulum to lipid droplets relies on surface modulation of the lipid droplet by the Arf1/COPI machinery.

To study odor-guided navigation of small animals such as worms and fly larvae, a novel flow chamber and odor sensor array are presented that better characterize the odors that the animal experiences.