A novel phenotypic screening platform based on immunofluorescent imaging of histone modifications enables accurate identification of cell fates and environmental perturbations.

The occupation of a sub-pocket near the Na⁺-binding site in D₂R by the Na⁺-insensitive antagonists is the structural basis for their greater inverse agonism than that of the Na⁺-sensitive ligands.

Contrary to previous findings, class A GPCRs share a common activation pathway that directly links ligand binding to G-protein activation, as revealed by novel quantitative analysis.

A multi-species chemical screening platform reveals a conserved role for p38 inhibition in modulating ryanodine receptor-related phenotypes and is adaptable to a range of neuromuscular disorders.

GDC-0810 is a novel, orally bioavailable SERD that exhibits robust pre-clinical activity in models of ER+ breast cancer, including models of tamoxifen resistance, and those that express the ERα mutations, ER.Y537S and ER.D538G.

Editors' Summary: This Replication Study has reproduced important parts of the original paper.

Engagement of both host and parasite signaling pathways proves a novel approach for developing improved anti-parasitic therapies.

A novel high-throughput, whole organism chemical screening platform was used to identify existing drugs that increase pancreatic beta-cell mass in zebrafish, implicating unique roles for the NF-κB and serotonergic signaling pathways in regulating pancreatic biology.

A high-throughput phenotypic human sperm screening platform was developed which allows for major drug discovery programmes for male contraception.

Discovery and characterisation of a novel allosteric inhibitor-binding site in human Bloom syndrome protein.