2,108 results found
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Epistasis and entrenchment of drug resistance in HIV-1 subtype B

    Avik Biswas et al.
    Drug resistance in HIV is the result of mutations, which affect fitness depending on epistatic interactions with the entire sequence background that varies within and between patient populations.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Transmission genetics of drug-resistant hepatitis C virus

    Nicholas van Buuren et al.
    Interactions between viral genomes within the same cells can impact the selection of drug-resistant variants and this has been finessed by hepatitis C virus.
    1. Cell Biology
    2. Computational and Systems Biology

    Perturbation biology nominates upstream–downstream drug combinations in RAF inhibitor resistant melanoma cells

    Anil Korkut et al.
    Data-driven systems biology models of signaling predict cellular response to untested perturbations and can nominate drug combinations to overcome drug resistance in cancer cells.
    1. Evolutionary Biology

    More effective drugs lead to harder selective sweeps in the evolution of drug resistance in HIV-1

    Alison F Feder et al.
    The transition from bad to good treatments for HIV was accompanied by a shift from soft sweeps of many drug resistance mutations spreading simultaneously to harder sweeps of one drug resistant genotype at a time.
    1. Chromosomes and Gene Expression

    Dominant drug targets suppress the emergence of antiviral resistance

    Elizabeth J Tanner et al.
    When antiviral compounds target oligomeric assemblages, the formation of chimeric oligomers within cells can negate selection for naturally occurring drug-resistant variants.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    The evolution of drug resistance in clinical isolates of Candida albicans

    Christopher B Ford et al.
    Loss-of-heterozygosity mutations, but not aneuploidies, are linked to the evolution of drug resistance in Candida albicans isolated from immunocompromised patients.
    1. Structural Biology and Molecular Biophysics

    Breast Cancer: How drug resistance takes shape

    Rinath Jeselsohn, Myles Brown
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    1. Cancer Biology
    2. Computational and Systems Biology

    A curative combination cancer therapy achieves high fractional cell killing through low cross-resistance and drug additivity

    Adam C Palmer et al.
    Drugs in a curative chemotherapy regimen are independently effective and resisted by different mechanisms, so cancer cells have little chance of surviving all drugs, and this benefit occurs without synergistic interactions.
    1. Microbiology and Infectious Disease

    ODELAM, rapid sequence-independent detection of drug resistance in isolates of Mycobacterium tuberculosis

    Thurston Herricks et al.
    Time-lapse live cell imaging of single Mycobacterium tuberculosis bacilli growing into small colonies enables their rapid phenotypic characterization including anti-microbial resistance and heteroresistance in clinical isolates.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Delayed antibiotic exposure induces population collapse in enterococcal communities with drug-resistant subpopulations

    Kelsey M Hallinen et al.
    Collapse of bacterial communities containing antibiotic-resistant and susceptible cells can be driven by increased population size or delayed drug exposure.

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