2,395 results found
    1. Cancer Biology
    2. Cell Biology

    Junction Mapper is a novel computer vision tool to decipher cell–cell contact phenotypes

    Helena Brezovjakova et al.
    Junction Mapper is a powerful new semi-automated software that provides a fingerprint of cell–cell contact morphometry and receptor density alterations.
    1. Cell Biology
    2. Ecology

    Ubiquitous macropinocytosis in anthozoans

    Philippe Ganot et al.
    Macropinocytosis, the process of non-specific endocytosis, is a major gateway for large volumes of surrounding medium and nanoparticles to coral cells.
    1. Neuroscience

    Quantitative properties of a feedback circuit predict frequency-dependent pattern separation

    Oliver Braganza et al.
    The feedback inhibitory microcircuit of the dentate gyrus likely boosts pattern separation during gamma oscillations.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A widely distributed metalloenzyme class enables gut microbial metabolism of host- and diet-derived catechols

    Vayu Maini Rekdal et al.
    A previously unrecognized group of metalloenzymes enables human gut microbes to metabolize dietary molecules and neurotransmitters and likely mediates interactions and metabolism among environmental microorganisms.
    1. Ecology
    2. Microbiology and Infectious Disease

    Bacterial interspecies interactions modulate pH-mediated antibiotic tolerance

    Andrés Aranda-Díaz et al.
    Shifts in pH that result from metabolic interactions between members of the Drosophila gut microbiota were sufficient to modulate Lactobacillus plantarum tolerance to the antibiotics rifampin and erythromycin.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Potential impact of outpatient stewardship interventions on antibiotic exposures of common bacterial pathogens

    Christine Tedijanto et al.
    Antibiotic stewardship in the outpatient setting can substantially reduce exposures of potential pathogens to common antibiotics, and complementary efforts are needed to reduce remaining exposures that occur in 'necessary' contexts.
    1. Neuroscience

    Shifting from fear to safety through deconditioning-update

    Bruno Popik et al.
    Deconditioning is a safe and efficient new approach to updating traumatic memories, in which fear memory is rewritten to a very low level in a long-lasting way.
    1. Neuroscience

    Opposite changes in APP processing and human Aβ levels in rats carrying either a protective or a pathogenic APP mutation

    Marc D Tambini et al.
    APP mutations that either cause or prevent dementia alter APP metabolism in a complex and opposite fashion, suggesting a link between multiple APP processing events, dementia and ageing-dependent cognitive decline.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation

    Matthew C Johnson, Justin M Kollman
    Assembly of the human enzyme inosine monophosphate dehydrogenase 2 into filaments promotes substrate-dependent resistance to feedback inhibition by downstream products, promoting increased flux during proliferative states.
    1. Structural Biology and Molecular Biophysics

    Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction

    Lan Wang et al.
    Msp1 recruits substrates at the open seam of the spiral oligomer and extracts them with functionally adapted elements.

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