4,373 results found
    1. Genetics and Genomics
    2. Cancer Biology

    Combinatorial CRISPR screen reveals FYN and KDM4 as targets for synergistic drug combination for treating triple negative breast cancer

    Tackhoon Kim, Byung-Sun Park ... Timothy K Lu
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Structural Biology and Molecular Biophysics

    Expanding Automated Multiconformer Ligand Modeling to Macrocycles and Fragments

    Jessica Flowers, Nathaniel Echols ... Stephanie A Wankowicz
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Cell Biology

    Novel Mechanism for Tubular Injury in Nephropathic Cystinosis

    Swastika Sur, Maggie Kerwin ... Minnie M Sarwal
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    SMARCAD1 and TOPBP1 contribute to heterochromatin maintenance at the transition from the 2C-like to the pluripotent state

    Ruben Sebastian-Perez, Shoma Nakagawa ... Maria Pia Cosma
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    • Incomplete
    1. Structural Biology and Molecular Biophysics

    PROTAC-induced Protein Structural Dynamics in Targeted Protein Degradation

    Kingsley Y Wu, Ta I Hung, Chia-en A Chang
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Synergistic effect of inhibiting CHK2 and DNA replication on cancer cell growth

    Flavie Coquel, Sing-Zong Ho ... Philippe Pasero
    Combined Inhibition of DNA replication and repair synergistically prevents tumor growth, representing a promising strategy for cancer therapy.
    1. Neuroscience

    Supralinear dendritic integration in murine dendrite-targeting interneurons

    Simonas Griesius, Amy Richardson, Dimitri Michael Kullmann
    NMDA receptors mediate prominent supralinear summation of clustered excitatory inputs to the dendrites of neurogliaform and oriens-lacunosum moleculare interneurons of the hippocampus, showing that these cells perform sub-cellular computations.
    1. Immunology and Inflammation

    Phosphoglycerate mutase regulates Treg differentiation through control of serine synthesis and one-carbon metabolism

    Wesley H Godfrey, Kaho Cho ... Michael D Kornberg
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Medicine
    2. Computational and Systems Biology

    Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats

    Hong Yang, Cheng Zhang ... Adil Mardinoglu
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid

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