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Microbiology and Infectious Disease
Kasugamycin potentiates rifampicin and limits emergence of resistance in
by specifically decreasing mycobacterial mistranslation
Swarnava Chaudhuri et al.
Kasugamycin potentiates rifampicin killing of
by targeting adaptive mistranslation.
Diminished responses to bodily threat and blunted interoception in suicide attempters
Danielle C DeVille et al.
People who have attempted suicide exhibit blunted sensory processing during breathing and pain perturbations, as well as lower heartbeat perception accuracy and reduced mid/posterior insula activity during interoceptive attention.
Sterol transfer by atypical cholesterol-binding NPC2 proteins in coral-algal symbiosis
Elizabeth Ann Hambleton et al.
Diversification of a conserved cholesterol binder drives functional replacement of cholesterol with symbiont-produced sterols in corals living in nutrient-poor environments.
Sexual dimorphism in striatal dopaminergic responses promotes monogamy in social songbirds
Kirill Tokarev et al.
Co-evolution of sexually dimorphic reinforcement systems for song can explain the coexistence of the seemingly contradictory traits of gregariousness and monogamy in social songbirds.
Synthetic protein interactions reveal a functional map of the cell
Lisa K Berry et al.
Forcing protein associations across the proteome reveals the cell's tolerance for diverse protein interactions and reveals the interactions that affect growth.
Point of View: Predictive regulation and human design
Why does the human regulatory system, which evolution tuned for small satisfactions, now constantly demand 'more'?
Inhibition of mutant EGFR in lung cancer cells triggers SOX2-FOXO6-dependent survival pathways
S Michael Rothenberg et al.
SOX2 causes resistance to anti-EGFR therapies in EGFR-mutant lung cancer.
Genetics and Genomics
Single cell functional genomics reveals the importance of mitochondria in cell-to-cell phenotypic variation
Riddhiman Dhar et al.
A genome-wide quantitative microscopy screen implicates mitochondria in single cell variation in proliferation and drug resistance in yeast.
Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids
Maria Daniela Garcia-Castillo et al.
Non-native synthetic short-chain glycosphingolipids fused to GLP-1 enable intestinal absorption with high bioavailability in vivo.
Chromosomes and Gene Expression
Paternal nicotine exposure alters hepatic xenobiotic metabolism in offspring
Markus P Vallaster et al.
A novel paternal effect based on nicotine exposure reveals that offspring exhibit an adaptive, yet nonspecific, resistance to multiple toxins.
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