237 results found
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    The giant mimivirus 1.2 Mb genome is elegantly organized into a 30-nm diameter helical protein shield

    Alejandro Villalta, Alain Schmitt ... Chantal Abergel
    As a Russian doll, mimivirus dsDNA genome is folded in a nucleocapsid-like structure enclosed in the nucleoid compartment, encased in the icosahedral capsid itself decorated by long glycosylated fibrils surprisingly made of the same protein as the genomic fiber.
    1. Immunology and Inflammation

    Ribosome biogenesis restricts innate immune responses to virus infection and DNA

    Christopher Bianco, Ian Mohr
    Ribosome production is unexpectedly integrated into innate cell-intrinsic responses that regulate double strand DNA-sensing and inflammatory cytokine induction in infected and uninfected cells.
    1. Ecology
    2. Microbiology and Infectious Disease

    Ecology and evolution of viruses infecting uncultivated SUP05 bacteria as revealed by single-cell- and meta-genomics

    Simon Roux, Alyse K Hawley ... Matthew B Sullivan
    Single-cell amplified genome sequencing uncovers virus-host interactions in uncultivated sulfur-oxidizing bacteria with relevance to coupled biogeochemical cycling in marine oxygen minimum zones.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Endoparasitoid lifestyle promotes endogenization and domestication of dsDNA viruses

    Benjamin Guinet, David Lepetit ... Julien Varaldi
    The propensity to endogenize and domesticate dsDNA viruses depends on lifestyle in Hymenoptera.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Ancient viral genomes reveal introduction of human pathogenic viruses into Mexico during the transatlantic slave trade

    Axel A Guzmán-Solís, Viridiana Villa-Islas ... María C Ávila Arcos
    The characterization of ancient B19V and HBV genotype A4 viruses circulating during Colonial epidemics provides new insights into the pathogens that were introduced to the Americas after the European colonization.
    1. Microbiology and Infectious Disease

    Research: A comprehensive and quantitative exploration of thousands of viral genomes

    Gita Mahmoudabadi, Rob Phillips
    A compendium of critical genomic numbers for viruses through the lenses of different viral classification systems.
    1. Structural Biology and Molecular Biophysics

    The phage L capsid decoration protein has a novel OB-fold and an unusual capsid binding strategy

    Rebecca L Newcomer, Jason R Schrad ... Kristin N Parent
    The structure of phage L's Dec demonstrates a new fold within this family of proteins, and shows modulation of capsid binding occurs through two sites, with site 1 being preferred.
    1. Ecology
    2. Genetics and Genomics

    Viral dark matter and virus–host interactions resolved from publicly available microbial genomes

    Simon Roux, Steven J Hallam ... Matthew B Sullivan
    From public microbial genomes, VirSorter revealed 12,498 viral genome sequences that expand the map of the global virosphere and whose analyses improve understanding of viral taxonomy, evolution and virus-host interactions.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Rapid cloning-free mutagenesis of new SARS-CoV-2 variants using a novel reverse genetics platform

    Enja Tatjana Kipfer, David Hauser ... Thomas Klimkait
    CLEVER enables the rapid manipulation and direct rescue of plus-strand RNA viruses with the shortest hands-on time to study viral variants of concern.
    1. Microbiology and Infectious Disease

    Human immunodeficiency virus-1 induces host genomic R-loops and preferentially integrates its genome near the R-loop regions

    Kiwon Park, Dohoon Lee ... Kwangseog Ahn
    Investigation of the role of triple-stranded nucleic acid, R-loops, in HIV-1 genome integration.

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