For the first time, the strength of homeostatic plasticity has been shown to be negatively regulated and the transcription factors responsible for this regulation have been identified.
Joris P Nassal, Fiona H Murphy ... Matthijs Verhage
In vivo live imaging reveals the trafficking dynamics of three cellular organelles in neocortical axons with single vesicle resolution and demonstrates activity-dependent changes.
Makenna M Morck, Debanjan Bhowmik ... Kathleen M Ruppel
Hypertrophic cardiomyopathy-causing mutations in the light chain-binding region of β-cardiac myosin's lever arm appear to disrupt myosin tail-based autoinhibition, while mutations in the pliant region of the lever arm reduce autoinhibition in the presence of actin and impact myosin’s powerstroke.
Manipulating nanoscale spacing of Fcγ receptors using DNA origami demonstrates that ligand clustering regulates receptor phosphorylation and phagocytosis.
The C terminal fusion partners of TAZ-CAMTA1, YAP-TFE3 and potentially other TAZ/YAP fusion proteins in cancer recruit epigenetic modifiers that modulate a baseline TEAD-based transcriptional program.
Ali Ekrem Yesilkanal, Dongbo Yang ... Marsha R Rosner
Low-dose treatment targeting multiple pathways of a pro-metastatic signaling network reduces the metastatic output of heterogeneous tumors while minimizing compensatory network activation.
Margaret E Torrence, Michael R MacArthur ... Brendan D Manning
ATF4 is a metabolic effector of mTORC1 signaling, co-opted to induce gene targets involved in amino acid synthesis, uptake, and tRNA charging, contributing to mTORC1-driven protein and glutathione synthesis.
