The mechanism underlying Shprintzen–Goldberg syndrome is solved and reveals that missense mutations in the transcriptional repressor SKI abolish ligand-induced SKI degradation, which results in attenuation of TGF-β transcriptional responses.
Alexandra B Byrne, Rebecca D McWhirter ... Marc Hammarlund
In C. elegans and mouse neurons, the balance between poly(ADP-ribose) glycohydrolases and poly(ADP-ribose) polymerases regulates axon regeneration downstream of DLK-1/MAPKKK signaling.
For the first time, the strength of homeostatic plasticity has been shown to be negatively regulated and the transcription factors responsible for this regulation have been identified.
The transcription factor NFIL3 is essential for the development of a committed bone marrow precursor that gives rise to all known innate lymphoid cell lineages in mice.
Margaret E Torrence, Michael R MacArthur ... Brendan D Manning
ATF4 is a metabolic effector of mTORC1 signaling, co-opted to induce gene targets involved in amino acid synthesis, uptake, and tRNA charging, contributing to mTORC1-driven protein and glutathione synthesis.
Evelyn L Eastwood, Kayla A Jara ... Gregory J Hannon
Heterochromatin formation at transposon loci depends on dimerisation of the effector complex that elicits co-transcriptional silencing and this requirement is fulfilled by co-option of the conserved dimerisation hub protein, Cut-up/LC8.
Calreticulin, beyond its known role as a chaperone, also serves as an endoplasmic reticulum repressor of ATF6⍺, selectively regulating one arm of the unfolded protein response.
