942 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A family of fluoride-specific ion channels with dual-topology architecture

    Randy B Stockbridge et al.
    Efflux of xenobiotic fluoride from microorganisms occurs through a novel family of ion channels with stringent selectivity for fluoride ion and dual-topology molecular architecture.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Regulation of multispanning membrane protein topology via post-translational annealing

    Reid C Van Lehn et al.
    Coarse-grained modeling reveals a new mechanism for multispanning membrane protein topogenesis, in which misintegrated configurations of the proteins undergo post-translational annealing to reach final, fully integrated multispanning topologies.
    1. Developmental Biology
    2. Evolutionary Biology

    Embryonic origin and serial homology of gill arches and paired fins in the skate, Leucoraja erinacea

    Victoria A Sleight, J Andrew Gillis
    Development from dual-origin mesenchyme with common competence explains anatomical parallels and shared patterning of the jawed vertebrate gill arch and paired fin skeletons.
    1. Structural Biology and Molecular Biophysics

    Mechanistic signs of double-barreled structure in a fluoride ion channel

    Nicholas B Last et al.
    Combining crystal structures with single-pore analysis of Fluc-family fluoride channel mutants demonstrates that Fluc channels have two separate fluoride ion permeation pathways within the channel complex.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structures of diverse poxin cGAMP nucleases reveal a widespread role for cGAS-STING evasion in host–pathogen conflict

    James B Eaglesham et al.
    Poxin enzymes are a diverse family of insect and viral 2′3′-cGAMP nucleases, which evolved from self-cleaving RNA virus accessory proteases.
    1. Microbiology and Infectious Disease

    Programmed genome editing of the omega-1 ribonuclease of the blood fluke, Schistosoma mansoni

    Wannaporn Ittiprasert et al.
    Gene knock-out of the omega-1 ribonuclease of Schistosoma mansoni eggs resulted in immunologically impaired phenotype, showcasing the novel application of CRISPR/Cas9 genome editing and utility for functional genomics in schistosomes.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structures of the scanning and engaged states of the mammalian SRP-ribosome complex

    Rebecca M Voorhees, Ramanujan S Hegde
    Structures of the signal recognition particle before and after it captures a transmembrane domain suggest how it chooses, engages, and shields its clients during membrane protein targeting to the endoplasmic reticulum.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Characterization of the ABC methionine transporter from Neisseria meningitidis reveals that lipidated MetQ is required for interaction

    Naima G Sharaf et al.
    NmMetQ is a lipoprotein that tethers to membranes via a lipid anchor and has dual function and localization, playing a role in NmMetNI-mediated transport at the inner membrane and moonlighting on the bacterial surface.
    1. Neuroscience

    Rapid regulation of vesicle priming explains synaptic facilitation despite heterogeneous vesicle:Ca2+ channel distances

    Janus RL Kobbersmed et al.
    Heterogeneous distances between vesicles and Ca2+-channels make synapses prone to short-term depression, however, Ca2+-dependent increases in the number of release-ready vesicles supports facilitation even with broadly distributed vesicle:Ca2+-channel distances.

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