5,130 results found
    1. Neuroscience

    Neurosecretory protein GL stimulates food intake, de novo lipogenesis, and onset of obesity

    Eiko Iwakoshi-Ukena et al.
    Neurosecretory protein GL, a previously unknown mammalian neuropeptide, is a novel hypothalamic factor which regulates feeding behavior and peripheral lipogenesis in animals.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    The P2X7 receptor forms a dye-permeable pore independent of its intracellular domain but dependent on membrane lipid composition

    Akira Karasawa et al.
    Functional reconstitution of a mammalian P2X7 receptor uncovers an intrinsic and lipid-dependent dye-permeable membrane pore.
    1. Cancer Biology
    2. Computational and Systems Biology

    Simultaneous enumeration of cancer and immune cell types from bulk tumor gene expression data

    Julien Racle et al.
    A novel method predicts cancer and immune cell types from bulk tumor gene expression data with the ability to consider uncharacterized and possibly highly variable cell types, which is validated in human genome.
    1. Neuroscience

    The hippocampus supports deliberation during value-based decisions

    Akram Bakkour et al.
    The deliberation involved in simple preference decisions, such as those between two familiar snacks, depends on the hippocampus.
    1. Structural Biology and Molecular Biophysics

    Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival

    Vladimir Chubanov et al.
    Mice deficient in the TRPM6 channel suffer from impaired prenatal development, shortened lifespan, growth deficit and disturbed energy balance due to a defect in epithelial Mg2+ uptake, thus highlighting a pivotal role of TRPM6 in organismal Mg2+ homeostasis.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Predicting mutational routes to new adaptive phenotypes

    Peter A Lind et al.
    A combination of genetics, experimental evolution and mathematical modelling defines information necessary to predict the outcome of short-term adaptive evolution.
    1. Neuroscience

    Early dysfunction and progressive degeneration of the subthalamic nucleus in mouse models of Huntington's disease

    Jeremy F Atherton et al.
    In mouse models of Huntington's disease, the subthalamic nucleus, which suppresses movements, also exhibits impaired glutamate homeostasis, NMDA receptor-dependent mitochondrial oxidant stress, firing disruption, and 30% neuronal loss.
    1. Neuroscience

    Human foveal cone photoreceptor topography and its dependence on eye length

    Yiyi Wang et al.
    Despite evidence of retinal stretching with eye growth, cone photoreceptor sampling density in the foveal center of humans actually increases with eye length.
    1. Neuroscience

    Motor selection dynamics in FEF explain the reaction time variance of saccades to single targets

    Christopher K Hauser et al.
    Oculomotor circuits are always busy planning the next eye movement, and this explains why, when a visual target appears, some eye movements toward it are produced very quickly whereas others take a long time to prepare.
    1. Neuroscience

    Divisive suppression explains high-precision firing and contrast adaptation in retinal ganglion cells

    Yuwei Cui et al.
    The convergence of two visual pathways at the level of retinal bipolar cells accounts for key features of ganglion cell responses.

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