1,395 results found
    1. Evolutionary Biology

    Metabolic co-dependence drives the evolutionarily ancient Hydra–Chlorella symbiosis

    Mayuko Hamada, Katja Schröder ... Thomas CG Bosch
    The symbiotic relationship between Hydra and Chlorella is driven by metabolic co-dependence and characterized by changes in the photobiont genome in terms of lack of genes essential in free-living algae.
    1. Neuroscience

    A positive feedback loop between Flower and PI(4,5)P2 at periactive zones controls bulk endocytosis in Drosophila

    Tsai-Ning Li, Yu-Jung Chen ... Chi-Kuang Yao
    The interplay between the Flower Ca2+ channel and PI(4,5)P2 spatiotemporally couples synaptic vesicle exocytosis to activity-dependent bulk endocytosis and synaptic vesicle reformation from bulk endosomes.
    1. Medicine
    2. Stem Cells and Regenerative Medicine

    Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19

    Courtney Tindle, MacKenzie Fuller ... Soumita Das
    An integrated stem cell-based disease modeling and computational approach demonstrates how proximal airway epithelium is critical for SARS-CoV-2 infectivity and distal alveolar cells are critical for simulating the host responses.
    1. Epidemiology and Global Health
    2. Medicine

    Conjunction of factors triggering waves of seasonal influenza

    Ishanu Chattopadhyay, Emre Kiciman ... Andrey Rzhetsky
    Three complementary computational approaches reveal a set of putative causes of initiation of pan-USA waves of influenza.
    1. Immunology and Inflammation

    Overriding impaired FPR chemotaxis signaling in diabetic neutrophil stimulates infection control in murine diabetic wound

    Ruchi Roy, Janet Zayas ... Sasha H Shafikhani
    Therapeutic potential of CCL3 for the treatment of diabetic foot ulcers if it is applied topically after the surgical debridement.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Osteoclast-mediated resorption primes the skeleton for successful integration during axolotl limb regeneration

    Camilo Riquelme-Guzmán, Stephanie L Tsai ... Tatiana Sandoval-Guzmán
    In vivo evaluation of mineralized skeleton in the regenerating axolotl limb reveals a significant osteoclast-driven resorption as an early event with long-lasting impact for tissue integration.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Transient intracellular acidification regulates the core transcriptional heat shock response

    Catherine G Triandafillou, Christopher D Katanski ... D Allan Drummond
    When translation stops, cells require intracellular acidification to turn on the conserved heat shock response during stress, and stress-triggered acidification (common in eukaryotes) is adaptive, promoting cell and population fitness.
    1. Neuroscience

    Dysfunctional hippocampal-prefrontal network underlies a multidimensional neuropsychiatric phenotype following early-life seizure

    Rafael Naime Ruggiero, Danilo Benette Marques ... Joao Pereira Leite
    The enduring impacts of early-life seizures on cognition and behavior are not attributed to neuronal loss but to disrupted hippocampus-prefrontal cortex network dynamics, heightened neuroinflammation, and altered dopaminergic transmission.
    1. Neuroscience

    miR-9 regulates basal ganglia-dependent developmental vocal learning and adult vocal performance in songbirds

    Zhimin Shi, Zoe Piccus ... XiaoChing Li
    Gene manipulation combined with behavior analysis reveals a role of miR-9 in modulating basal-ganglia-dependent developmental vocal learning and adult vocal performance via regulating the FOXP1/FOXP2 gene network and dopamine signaling in songbirds.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Generic injuries are sufficient to induce ectopic Wnt organizers in Hydra

    Jack F Cazet, Adrienne Cho, Celina E Juliano
    Injuries activate the oral identity-specifying canonical Wnt signaling pathway in Hydra, which can trigger head regeneration in permissive tissue contexts created by the absence of pre-existing organizers.

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