3,672 results found
    1. Computational and Systems Biology

    Evolutionary dynamics of incubation periods

    Bertrand Ottino-Loffler et al.
    Evolutionary graph theory solves the longstanding puzzle of why diverse infectious diseases and cancers show similar (approximately lognormal) distributions of their incubation periods.
    1. Computational and Systems Biology
    2. Neuroscience

    Sodium channels implement a molecular leaky integrator that detects action potentials and regulates neuronal firing

    Marco A Navarro et al.
    Kinetic interactions between sodium channels and auxiliary factors create a molecular computational engine that can sense and regulate cellular excitability.
    1. Neuroscience

    Acute perturbation of Pet1-neuron activity in neonatal mice impairs cardiorespiratory homeostatic recovery

    Ryan T Dosumu-Johnson et al.
    Pet1 neurons actively maintain cardiorespiratory tone and dynamic range in mouse neonates and critically support the recovery response to apneas, informing brain findings in the sudden infant death syndrome.
    1. Neuroscience

    Temporal transitions of spontaneous brain activity

    Zhiwei Ma, Nanyin Zhang
    Analysis of resting-state fMRI data revealed nonrandom temporal transitions between spontaneous brain activity patterns in both awake rats and humans.
    1. Neuroscience

    Temporally delayed linear modelling (TDLM) measures replay in both animals and humans

    Yunzhe Liu et al.
    Temporally delayed linear modelling provides a domain-general linear framework for sequence detection and statistical testing, and is able to detect replays in both human neuroimaging and animal electrophysiology.
    1. Computational and Systems Biology
    2. Developmental Biology

    High-throughput mathematical analysis identifies Turing networks for patterning with equally diffusing signals

    Luciano Marcon et al.
    Realistic reaction-diffusion signaling networks that include cell-autonomous factors can robustly form self-organizing spatial patterns for any combination of diffusion coefficients without requiring differential diffusivity.
    1. Developmental Biology
    2. Plant Biology

    A stochastic multicellular model identifies biological watermarks from disorders in self-organized patterns of phyllotaxis

    Yassin Refahi et al.
    A stochastic model of phyllotaxis can explain the striking irregularities observed in the spiral patterns of plants and predicts that perturbation patterns provide key information about the underlying biochemical mechanisms.
    1. Ecology
    2. Physics of Living Systems

    Microbial consortia at steady supply

    Thibaud Taillefumier et al.
    In a consumer-resource model obeying the physical requirement of flux conservation, metabolic competition between microbes yields consortia of cell types that collectively resist invasion via optimal use of resources.
    1. Computational and Systems Biology
    2. Ecology

    Trade-off shapes diversity in eco-evolutionary dynamics

    Farnoush Farahpour et al.
    In a minimalistic, generic model of competitive communities in which evolution is constrained by life-history trade-offs, stable biodiversity emerges with species adapted to different functional niches.
    1. Computational and Systems Biology
    2. Developmental Biology

    Motion sensing superpixels (MOSES) is a systematic computational framework to quantify and discover cellular motion phenotypes

    Felix Y Zhou et al.
    A new computational framework provides a flexible and general approach for single and collective biological motion characterisation and phenotyping ideally suited for high-throughput timelapse screens.

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