A theoretical framework for the growth of microtubules quantifies the roles of geometry, mechanics, kinetics and randomness and provides a phase diagram for dynamic instability in these self-assembled polymers.
Neuronal networks balance flexibility with stability by allowing the firing rate of individual neurons within a network to vary over time, while ensuring that the average firing rate across the network remains constant.
Fluctuation of biomarkers is a novel way of studying system stability during stable and unstable states of health and disease, revealing the systems' ability to cope with external perturbations.
Mechanical interactions between bacterial species with different motility characteristics play an important role in spatial-temporal dynamics of multi-species bacterial colonies and can lead to formation of complex patterns.
Combining quantitative biological experiment and physical description of actomyosin cortex reveals a contractile instability in the cortex of C. elegans embryo, and its biochemical control in order to robustly drive morphogenetic events.
Identifying the patient-specific mutation that shifted the antibody light chain to the deadly fibrillar species provides new insight in the molecular pathogenesis of AL amyloidosis.
Crowding and metabolites in a simulated cellular environment alter protein conformations, modulate interactions of functionally related proteins, and lead to significant dynamic heterogeneity.
A principled statistical segmentation of fruit fly walking leads to a compact model of immediate actions that can reproduce the unique behavioral sequences of individual flies.
Computational modeling and molecular-biological analysis reveal the role of mechanical force and downstream Yap signaling in growth control during the development and regeneration of sensory epithelium of the inner ear.