4,831 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A dynamic charge-charge interaction modulates PP2A:B56 substrate recruitment

    Xinru Wang et al.
    A novel dynamic charge-charge interaction between B56 and a subset of PP2A-B56 substrates is essential for substrate specificity, dephosphorylation and, for KIF4A, binding condensin I.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Widespread premature transcription termination of Arabidopsis thaliana NLR genes by the spen protein FPA

    Matthew T Parker et al.
    The expression of Arabidopsis NLR immune response genes is modulated by premature transcription termination, and this has implications for understanding NLR regulation and evolutionary dynamics.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Multiple sources of slow activity fluctuations in a bacterial chemosensory network

    Remy Colin et al.
    Single-cell FRET measurements reveal large temporal activity fluctuations within this signaling pathway in Escherichia coli, caused by stochasticity of receptor methylation combined with allosteric interactions and slow rearrangements within receptor clusters.
    1. Structural Biology and Molecular Biophysics

    Gating mechanisms during actin filament elongation by formins

    Fikret Aydin et al.
    Formins slow elongation of actin filament by either sterically blocking the addition of actin subunits or flattening the helical twist of the filament end.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Simple biochemical features underlie transcriptional activation domain diversity and dynamic, fuzzy binding to Mediator

    Adrian L Sanborn et al.
    Transcriptional activation domains achieve rapid, dynamic, specific interaction with Mediator through binding of an unstructured peptide to multiple hydrophobic surfaces without particular amino acid side chain interactions.
    1. Cell Biology

    In vivo reconstitution finds multivalent RNA–RNA interactions as drivers of mesh-like condensates

    Weirui Ma et al.
    Binding of a multivalent RNA-binding protein to mRNAs that are able to form pervasive RNA–RNA interactions induces formation of mesh-like condensates, whereas binding of mostly structured mRNAs induces sphere-like condensates.
    1. Stem Cells and Regenerative Medicine
    2. Chromosomes and Gene Expression

    Global reorganisation of cis-regulatory units upon lineage commitment of human embryonic stem cells

    Paula Freire-Pritchett et al.
    Promoter interactome maps in human embryonic stem cells (ESCs) and ESC-derived early neuroectodermal progenitors link distal enhancers to putative target genes, reveal lineage-specific cis-regulatory architecture and shed light on the logic of gene regulation by multiple enhancers.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    High-resolution structures of multiple 5-HT3AR-setron complexes reveal a novel mechanism of competitive inhibition

    Sandip Basak et al.
    Cryo-electron microscopic structures of 5-HT3A receptor in complex with first and second generations of clinically used setron reveal the molecular basis for their binding modes and mechanisms of inhibitory action.
    1. Biochemistry and Chemical Biology

    The structural determinants of PH domain-mediated regulation of Akt revealed by segmental labeling

    Nam Chu et al.
    NMR and biochemical analysis reveal new insights into how the critical protein kinase Akt is regulated by phosphorylation and is inhibited by an experimental therapeutic.
    1. Cell Biology
    2. Physics of Living Systems

    Stoichiometric interactions explain spindle dynamics and scaling across 100 million years of nematode evolution

    Reza Farhadifar et al.
    Stoichiometric interactions between microtubules and cortical force-generators set spindle size, position and dynamics, and its scaling with cell size in nematode species.

Refine your results by:

Type
Research categories