277 results found
    1. Cell Biology

    Uncoupling of dynamin polymerization and GTPase activity revealed by the conformation-specific nanobody dynab

    Valentina Galli et al.
    Uncoupling of dynamin polymerization and GTPase activity can be induced with dynamin, which allows in vivo visualization of its activity at endocytic pits.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Lis1 regulates dynein by sterically blocking its mechanochemical cycle

    Katerina Toropova et al.
    Structural and functional studies reveal how a ubiquitous regulator of dynein keeps the microtubule-based motor in a persistent track-bound state.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Cytoplasmic dynein crosslinks and slides anti-parallel microtubules using its two motor domains

    Marvin E Tanenbaum et al.
    The motor domains of dynein are sufficient to crosslink microtubules and slide them antiparallel to each other.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Dynamic clustering of dynamin-amphiphysin helices regulates membrane constriction and fission coupled with GTP hydrolysis

    Tetsuya Takeda et al.
    A new approach using combination of electron microscopy (EM) and high-speed atomic force microscopy (HS-AFM) clearly demonstrates dynamics of dynamin-amphiphysin complexes during membrane constriction and fission suggesting a novel 'clusterase' model of the dynamin-mediated membrane fission.
    1. Cell Biology

    Interplay between kinesin-1 and cortical dynein during axonal outgrowth and microtubule organization in Drosophila neurons

    Urko del Castillo et al.
    Cortical dynein organizes unipolar microtubule arrays in Drosophila axons by expelling minus-end-out microtubules.
    1. Cell Biology

    NuMA recruits dynein activity to microtubule minus-ends at mitosis

    Christina L Hueschen et al.
    At mitosis, NuMA recruits dynein-dynactin to microtubule minus-ends, enabling robust microtubule clustering and the emergence of spindle poles.
    1. Cell Biology

    Lissencephaly-1 is a context-dependent regulator of the human dynein complex

    Janina Baumbach et al.
    An in vitro reconstitution approach reveals context-dependent roles of Lissencephaly-1 in the regulation of dynein-dynactin behaviour on dynamic microtubules.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A Ras-like domain in the light intermediate chain bridges the dynein motor to a cargo-binding region

    Courtney M Schroeder et al.
    The dynein light intermediate chain is a member of the G protein superfamily and links the motor to several intracellular cargo adaptors.
    1. Cell Biology
    2. Neuroscience

    Dynamin phosphorylation controls optimization of endocytosis for brief action potential bursts

    Moritz Armbruster et al.
    The recycling of transmitter vesicles at synapses shows calcium-dependent regulation that depends on the phosphorylation status of an enzyme called dynamin.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Structural inhibition of dynamin-mediated membrane fission by endophilin

    Annika Hohendahl et al.
    The BAR protein endophilin spaces out turns of the dynamin helix, blocking its active conformational change and membrane fission.

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