549 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Endothelial pannexin 1–TRPV4 channel signaling lowers pulmonary arterial pressure in mice

    Zdravka Daneva et al.
    Endothelial pannexin 1-P2Y2 purinergic receptor-TRPV4 channel signaling, facilitated by caveolin-1, is a novel pathway for lowering pulmonary arterial pressure.
    1. Cell Biology
    2. Immunology and Inflammation

    Endothelial junctional membrane protrusions serve as hotspots for neutrophil transmigration

    Janine JG Arts et al.
    Neutrophils use dorsal membrane protrusions of endothelial cells to cross the vascular wall.
    1. Neuroscience

    Activity-dependent regulation of mitochondrial motility in developing cortical dendrites

    Catia AP Silva et al.
    Naturally occurring activity in the developing brain regulates mitochondrial motility such that mitochondria stop at active synapses, which is probably a fundamental process in brain wiring.
    1. Cell Biology
    2. Developmental Biology

    Quantitative mapping of dense microtubule arrays in mammalian neurons

    Eugene A Katrukha et al.
    Quantitative super-resolution light microscopy reveals the relative abundance and three-dimensional organization of different microtubule subsets within dendrites of mammalian neurons.
    1. Computational and Systems Biology
    2. Neuroscience

    Neuronal timescales are functionally dynamic and shaped by cortical microarchitecture

    Richard Gao et al.
    Invasive electrophysiological recording measures neuronal transmembrane current timescales across human cortex, which lengthens from sensory to association regions, follows variations in ion channel expressions, and alters with behavior and aging.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Dynamic persistence of UPEC intracellular bacterial communities in a human bladder-chip model of urinary tract infection

    Kunal Sharma et al.
    Live-cell imaging captures the heterogenity of bacterial growth within intracellular bacterial communities and demonstrates that the constituent bacteria are protected from clearance by antibiotics delivered with a physiologically relevant pharmacodynamic profile.
    1. Neuroscience

    Learning to stand with unexpected sensorimotor delays

    Brandon G Rasman et al.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Nucleo-cytoplasmic shuttling of splicing factor SRSF1 is required for development and cilia function

    Fiona Haward et al.
    A mouse model where the splicing factor SRSF1 was prevented from accumulating in the cytoplasm revealed reduced translation of thousands of mRNAs and postnatal phenotypes particularly affecting multiciliated cells.

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