Different dynorphins, which signal similarly from the cell surface, can differentially localize G protein-coupled receptors to specific subcellular compartments and cause divergent receptor fates and distinct spatiotemporal patterns of signaling.

Heavy alcohol drinking primes dynorphin /kappa opioid systems in the bed nucleus of the stria terminalis to alter stress responses in mice.

Kisspeptin neurons in the hypothalamus release peptide and amino acid neurotransmitters that work together to coordinate the activity of gonadotropin-releasing hormone neurons and subsequent release of reproductive hormones.

The neural mechanisms that underlie the maintenance of social bonds between prairie voles suggest that social support networks may be a powerful way of treating addiction.

The arcuate nucleus kisspeptin neurons express multiple transmitters but use only the neuropeptide kisspeptin to drive the episodic secretion of gonadotropin-releasing hormone.

In vivo detection of optically evoked endogenous opioid peptides reveals anatomically distinct release profiles.

Warm-activated parabrachial neurons contain overlapping dynorphin and enkephalin expressing subpopulations, project to preoptic hypothalamus, and mediate behavioral and physiological thermal defenses behaviors.

Pulse generation is an emergent property of the arcuate kisspeptin network that is regulated throughout the ovarian cycle via coordinated changes in neuronal communication and basal activation.

Rats exposed to a single stressful event experience days-long constitutive activation of the kappa opioid receptor at inhibitory synapses in part of the brain’s reward system, which increases their drug-seeking behavior.

Subtraction analysis using novel Orexin-Flp mice isolated physiological importance of orexin peptides.