Voice your concerns about research culture and research communication: Have your say in our 7th annual survey.
275 results found
    1. Biochemistry and Chemical Biology

    eIF1A residues implicated in cancer stabilize translation preinitiation complexes and favor suboptimal initiation sites in yeast

    Pilar Martin-Marcos et al.
    Substitutions in general translation initiation factor eIF1A found as recurring somatic mutations in uveal melanoma destabilize the closed conformation of the preinitiation complex at the start codon and increase discrimination against suboptimal initiation codons genome-wide.
    1. Structural Biology and Molecular Biophysics

    Translational initiation factor eIF5 replaces eIF1 on the 40S ribosomal subunit to promote start-codon recognition

    Jose Luis Llácer et al.
    The N-terminal domain (NTD) of the initiation factor eIF5 bound to the 40S subunit at the precise location vacated by eIF1 promotes tRNAi accommodation at AUG codons.
    1. Chromosomes and Gene Expression

    Distinct interactions of eIF4A and eIF4E with RNA helicase Ded1 stimulate translation in vivo

    Suna Gulay et al.
    Interactions of eIF4A and eIF4E with specific amino-acids in the N-terminal domain of DEAD-box helicase Ded1 enhance bulk polysome assembly and translation of reporter mRNAs with structured leaders in vivo.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Translation initiation by the hepatitis C virus IRES requires eIF1A and ribosomal complex remodeling

    Zane A Jaafar et al.
    The hepatitis C virus IRES binds and remodels preassembled eukaryotic translation preinitiation complexes, using specific initiation factor protein within a "bacterial-like" mode of initiation that can function in both stressed and unstressed cells.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Yeast eIF4A enhances recruitment of mRNAs regardless of their structural complexity

    Paul Yourik et al.
    Eukaryotic translation initiation factor 4A is stimulated by the ribosomal pre-initiation complex and promotes the recruitment of mRNAs regardless of their degree of structure.
    1. Biochemistry and Chemical Biology

    Coupling between the DEAD-box RNA helicases Ded1p and eIF4A

    Zhaofeng Gao et al.
    Ded1p and eIF4A, two RNA helicases that function in eukaryotic translation initiation, interact physically with each other and with the scaffolding protein eIF4G.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Cap-proximal nucleotides via differential eIF4E binding and alternative promoter usage mediate translational response to energy stress

    Ana Tamarkin-Ben-Harush et al.
    Differential eIF4E binding to transcription initiation nucleotides and alternative promoter usage of eIF1A, PABP and other genes are involved in the response of the translation machinery to energy stress.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    The insulin receptor cellular IRES confers resistance to eIF4A inhibition

    Calla M Olson et al.
    Utilizing a conserved mechanism, a ribosome can initiate translation from a site within the insulin receptor mRNA to maintain protein synthesis even when standard mechanisms of initiating translation have been inhibited by stress.
    1. Neuroscience

    Role of the visual experience-dependent nascent proteome in neuronal plasticity

    Han-Hsuan Liu et al.
    A screen of visual-experience induced changes in newly-synthesized proteins in Xenopus optic tectum identifies unexpected candidate plasticity proteins.
    1. Cell Biology
    2. Neuroscience

    Restraint of presynaptic protein levels by Wnd/DLK signaling mediates synaptic defects associated with the kinesin-3 motor Unc-104

    Jiaxing Li et al.
    Synaptic defects previously attributed to loss of kinesin function are found to be mediated by the Wnd/DLK axonal injury signaling pathway, which restrains the total levels of presynaptic proteins in response to their accumulation.

Refine your results by:

Type
Research categories