92 results found
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Cap-proximal nucleotides via differential eIF4E binding and alternative promoter usage mediate translational response to energy stress

    Ana Tamarkin-Ben-Harush et al.
    Differential eIF4E binding to transcription initiation nucleotides and alternative promoter usage of eIF1A, PABP and other genes are involved in the response of the translation machinery to energy stress.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Yeast Ded1 promotes 48S translation pre-initiation complex assembly in an mRNA-specific and eIF4F-dependent manner

    Neha Gupta et al.
    Yeast RNA helicase Ded1 stimulates ribosome recruitment of structure-laden native mRNAs in a reconstituted system by interactions between domains in Ded1 and initiation factor eIF4G that stabilizes a Ded1-eIF4F complex.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    The insulin receptor cellular IRES confers resistance to eIF4A inhibition

    Calla M Olson et al.
    Utilizing a conserved mechanism, a ribosome can initiate translation from a site within the insulin receptor mRNA to maintain protein synthesis even when standard mechanisms of initiating translation have been inhibited by stress.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs

    Roni M Lahr et al.
    La-related protein 1 specifically and directly binds the 5' cap and first nucleotide of mRNAs encoding ribosomal proteins and translation factors, inhibiting the assembly of translation initiation factors on these messages and therefore their translation.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Yeast eIF4A enhances recruitment of mRNAs regardless of their structural complexity

    Paul Yourik et al.
    Eukaryotic translation initiation factor 4A is stimulated by the ribosomal pre-initiation complex and promotes the recruitment of mRNAs regardless of their degree of structure.
    1. Biochemistry and Chemical Biology

    Coupling between the DEAD-box RNA helicases Ded1p and eIF4A

    Zhaofeng Gao et al.
    Ded1p and eIF4A, two RNA helicases that function in eukaryotic translation initiation, interact physically with each other and with the scaffolding protein eIF4G.
    1. Cancer Biology
    2. Cell Biology

    The eukaryotic translation initiation factor eIF4E harnesses hyaluronan production to drive its malignant activity

    Hiba Ahmad Zahreddine et al.
    The eukaryotic translation initiation factor eIF4E induces hyaluronic acid (HA) synthesis to drive cancer metastasis which can be reversed following eIF4E inhibition and HA degradation.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Translational control of nociception via 4E-binding protein 1

    Arkady Khoutorsky et al.
    The mTOR downstream effector eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) regulates mechanical nociception via translational control of synaptic transmission in the spinal cord.
    1. Biochemistry and Chemical Biology

    LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs

    Sungki Hong et al.
    LARP1 turns off and on the translation of an essential class of mRNAs by acting as a key effecter and regulator for mTORC1.
    1. Biochemistry and Chemical Biology

    The ribosomal protein Asc1/RACK1 is required for efficient translation of short mRNAs

    Mary K Thompson et al.
    Asc1/RACK1 promotes the translation of mRNAs associated with the translational closed loop complex, which have short open reading frames and encode proteins required for core metabolic processes.

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