262 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome

    Rati Verma, Robert S Oania ... Raymond J Deshaies
    The enzyme that collaborates with ubiquitin ligases to promote the release of defective polypeptides from stalled ribosomes in a process named ribosome-associated degradations has been identified as the ATPase Cdc48.
    1. Cell Biology
    2. Neuroscience

    Pharmacological brake-release of mRNA translation enhances cognitive memory

    Carmela Sidrauski, Diego Acosta-Alvear ... Peter Walter
    A compound that prevents stressors such as UV light and viral infection from downregulating protein synthesis inside cells improves memory performance in mice.
    1. Plant Biology

    Temporal transcriptional response to ethylene gas drives growth hormone cross-regulation in Arabidopsis

    Katherine Noelani Chang, Shan Zhong ... Joseph R Ecker
    The plant hormone ethylene regulates the expression of multiple genes in the model plant Arabidopsis, including those that respond to other hormones.
    1. Developmental Biology

    An essential role for maternal control of Nodal signaling

    Pooja Kumari, Patrick C Gilligan ... Karuna Sampath
    Regulation of conserved Nodal factors by a maternal protein ensures that Nodal signaling is repressed until the appropriate time in embryonic development.
    1. Biochemistry and Chemical Biology

    Global cellular response to chemotherapy-induced apoptosis

    Arun P Wiita, Etay Ziv ... James A Wells
    The simultaneous monitoring of transcription, translational control, protein production and proteolysis in the same system can improve our understanding of how cancer cells respond to chemotherapy.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The translational landscape of the splicing factor SRSF1 and its role in mitosis

    Magdalena M Maslon, Sara R Heras ... Javier F Cáceres
    Identifying the translational targets of the shuttling protein, SRSF1, reveals that it is needed for normal cell division, and suggests that it couples pre-mRNA splicing and translation.
    1. Plant Biology

    Cell elongation is regulated through a central circuit of interacting transcription factors in the Arabidopsis hypocotyl

    Eunkyoo Oh, Jia-Ying Zhu ... Zhi-Yong Wang
    Signals from major hormones and the environment are integrated in the Arabidopsis hypocotyl to control gene expression and plant stem elongation.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine

    Wilson Wong, Xiao-chen Bai ... Sjors HW Scheres
    The molecular mechanism behind how emetine inhibits the ribosome of the human malaria parasite, along with structural details of the complex formed, is revealed at high resolution using cryo-electron microscopy.
    1. Developmental Biology
    2. Neuroscience

    Regulation of retinal axon growth by secreted Vax1 homeodomain protein

    Namsuk Kim, Kwang Wook Min ... Jin Woo Kim
    Secreted Vax1 homeodomain protein supports the development of optic chiasm by directly acting at the retinal ganglion cell axon.

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