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  1. Racism in Science: We need to act now

    Michael B Eisen
    eLife, like the rest of science, must tackle the many inequalities experienced by Black scientists.
    Editorial
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  2. Scientific Publishing: Room at the top

    Randy Schekman
    Five years after eLife published its first papers, we reflect on our consultative approach to peer review, the challenges of reproducibility, and the need to reform how published research is assessed.
    Editorial
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  3. Peer Review: The pleasure of publishing

    Vivek Malhotra, Eve Marder
    When assessing manuscripts eLife editors look for a combination of rigour and insight, along with results and ideas that make other researchers think differently about their subject.
    Editorial
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  4. Peer Review: Consultative review is worth the wait

    Stuart RF King
    Editors, reviewers and authors share their experiences of consultative peer review at eLife.
  5. Scientific Publishing: Advancing research

    Mark Patterson et al.
    eLife has introduced a new type of article–the Research Advance–that allows the authors of an eLife paper to publish results that build on their original research paper.
    Editorial
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  6. Scientific Publishing: Progress and promise

    Randy Schekman
    As he prepares to step down as the Editor-in-Chief of eLife, Randy Schekman reflects on the origins of the journal, the eLife approach to peer review, and current challenges in scientific publishing.
    Editorial
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  7. Scientific Publishing: Beyond scoops to best practices

    Eve Marder
    Authors submitting a manuscript to eLife are encouraged to upload it to a recognized preprint server at the same time in order to make their results available as quickly and as widely as possible.
    Editorial
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  8. Scientific Publishing: Coming soon to a screen near you

    Melissa Harrison
    As eLife starts to publish the accepted versions of certain Research Articles, we explain what happens once a manuscript has been accepted for publication.
    Editorial
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    1. Neuroscience

    Modulation of anxiety and fear via distinct intrahippocampal circuits

    Elif Engin et al.
    The hippocampus features a double dissociation in its circuits with respect to the regulation of fear and anxiety, with CA3 and the dentate gyrus implicated in anxiety and CA1 in fear.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    An unfolded protein-induced conformational switch activates mammalian IRE1

    G Elif Karagöz et al.
    ER-stress sensing mechanism of the unfolded protein response sensor/transducer IRE1 is conserved from yeast to mammals, where in mammals, unfolded protein binding to IRE1's ER lumenal domain is coupled to its oligomerization and activation through an allosteric conformational change.