119 results found
    1. Neuroscience
    2. Genetics and Genomics

    Regulatory changes in two chemoreceptor genes contribute to a Caenorhabditis elegans QTL for foraging behavior

    Joshua S Greene et al.
    A quantitative trait locus that includes two pheromone receptor genes affects foraging behavior; for one of the genes, the two alleles of the QTL have opposite effects because of distinct sites of expression.
    1. Genetics and Genomics
    2. Neuroscience

    Hypothalamic transcriptomes of 99 mouse strains reveal trans eQTL hotspots, splicing QTLs and novel non-coding genes

    Yehudit Hasin-Brumshtein et al.
    In depth characterization of gene expression in the mouse hypothalamus will facilitate understanding of the molecular pathways that affect metabolic traits and discovers new genes associated with these pathways.
    1. Genetics and Genomics

    Determining the genetic basis of anthracycline-cardiotoxicity by molecular response QTL mapping in induced cardiomyocytes

    David A Knowles et al.
    Genetic variants that modulate transcriptomic response to doxorubicin in human iPSC-derived cardiomyocytes are predictive of cardiac damage and in vivo sensitivity to anthracycline cardiotoxicity.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Co-expression analysis reveals interpretable gene modules controlled by trans-acting genetic variants

    Liis Kolberg et al.
    Co-expression analysis combined with functional enrichment improves the detection and prioritisation of trans-eQTLs when applied to emerging cell-type-specific datasets.
    1. Cell Biology
    2. Genetics and Genomics

    A trans-eQTL network regulates osteoclast multinucleation and bone mass

    Marie Pereira et al.
    MMnet is a conserved, trans-regulated gene network that controls skeletal homeostasis through osteoclast multinucleation and bone resorptive function.
    1. Genetics and Genomics

    Human Genetics: Immune response is a personal matter

    Pedro G Ferreira, Emmanouil T Dermitzakis
    Insight
    Available as:
    • HTML
    • PDF
    1. Genetics and Genomics

    Science Forum: The single-cell eQTLGen consortium

    MGP van der Wijst et al.
    The single-cell eQTLGen consortium aims to pinpoint the cellular contexts in which disease-causing genetic variants affect gene expression and its regulation.
    1. Genetics and Genomics

    Alternative polyadenylation mediates genetic regulation of gene expression

    Briana E Mittleman et al.
    Genetic variation can impact multiple levels of gene regulation and disease through alternative polyadenylation.
    1. Cell Biology
    2. Physics of Living Systems

    Stoichiometric interactions explain spindle dynamics and scaling across 100 million years of nematode evolution

    Reza Farhadifar et al.
    Stoichiometric interactions between microtubules and cortical force-generators set spindle size, position and dynamics, and its scaling with cell size in nematode species.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Systematic genetic analysis of the MHC region reveals mechanistic underpinnings of HLA type associations with disease

    Matteo D'Antonio et al.
    Analysis of the major histocompatibility complex using whole genome sequencing and RNA-seq data from hundreds of individuals provides novel insights into mechanisms underlying associations of this interval with disease.

Refine your results by:

Type
Research categories