In silico modeling identify allosteric CXCR4 modulators that block receptor nanoclustering and chemoattractant sensing without affecting other CXCL12-mediated functions, and reduce tumorigenesis and metastasis in a zebrafish model.

Pupil-linked arousal dynamics are influenced more strongly by high-level internal belief states than by low-level sensory events during decision-making.

Boundary:boundary pairing generates either stem-loop or circle-loop TADs, and these loop topologies differ in how they impact chromosome structure and genetic activities.

The global ensemble forecasting niche modelling of 11 vector competent triatomine species revealed climatic suitable regions outside their native distribution including the cosmopolitan vector Triatoma rubrofasciata.

Neural representations of both general event schemas and story-specific details predict memory performance in narrative recall, with distinct brain networks tracking schematic information during perception versus retrieval.

After playing violent video games for 7 hr over the course of 2 weeks, human male participants show neither signs of decreased empathy for the pain of another person nor of decreased responsivity to violent images.

SI topographic finger maps of older adults show signs of cortical aging but do not show classical hallmarks of cortical de-differentiation.

In the processing of spoken narratives, bottom-up acoustic cues and top-down linguistic knowledge separately contribute to neural construction of linguistic units.

Lifelong continuous reproduction, late-life investment into female sexuals, a short phase of senescence, and reproductive death characterize the life history of Cardiocondyla obscurior ant queens.

Fluctuations of spectral power in large-scale cortical networks shape behavior in a perceptual decision-making task through arousal-linked and arousal-independent mechanisms.