2,223 results found
    1. Neuroscience

    Interneuron-specific gamma synchronization indexes cue uncertainty and prediction errors in lateral prefrontal and anterior cingulate cortex

    Kianoush Banaie Boroujeni, Paul Tiesinga, Thilo Womelsdorf
    A fast spiking interneuron sub-type in medial and lateral prefrontal cortex fires and gamma-synchronizes prominently during adaptive learning of reward values when outcomes are uncertain and choice options have similar values.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Dynamic change of electrostatic field in TMEM16F permeation pathway shifts its ion selectivity

    Wenlei Ye, Tina W Han ... Lily Yeh Jan
    TMEM16F shifts its ion selectivity in response to change of intracellular Ca2+, membrane potential and ionic strength.
    1. Neuroscience

    Striatal action-value neurons reconsidered

    Lotem Elber-Dorozko, Yonatan Loewenstein
    The numerous reports in support of action-value representation in the striatum are based on statistical analyses that are subject to two critical confounds and, thus, this long-held belief of striatal action-value representation should be retested using different experiments and analyses.
    1. Neuroscience

    Neural pattern change during encoding of a narrative predicts retrospective duration estimates

    Olga Lositsky, Janice Chen ... Kenneth A Norman
    Judgments of how much time elapsed between two events in a story are predicted by changes in fMRI activity patterns.
    1. Neuroscience

    Monkeys exhibit human-like gaze biases in economic decisions

    Shira M Lupkin, Vincent B McGinty
    A novel animal model of economic decision-making captures complex patterns of choice behavior similar to those of humans, opening the way for mechanistic studies to probe the neural basis for this important form of executive function.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Complementary evolution of coding and noncoding sequence underlies mammalian hairlessness

    Amanda Kowalczyk, Maria Chikina, Nathan Clark
    Studying the genomes of mammals with sparse hair covering identifies specific genes and regulatory regions responsible for the formation of hair and skin, some of which were previously unrecognized.
    1. Neuroscience

    Performance in even a simple perceptual task depends on mouse secondary visual areas

    Hannah C Goldbach, Bradley Akitake ... Mark H Histed
    In a simple visual task, that in principle could be performed using information in V1 alone, perturbations of secondary visual areas impair perception.
    1. Computational and Systems Biology
    2. Stem Cells and Regenerative Medicine

    Self-assembling manifolds in single-cell RNA sequencing data

    Alexander J Tarashansky, Yuan Xue ... Bo Wang
    An iterative self-assembling algorithm identifies the intrinsic structures in single-cell transcriptomic data and helps to discover new cell populations that are undetectable by existing methods.
    1. Neuroscience

    Motoneuron Wnts regulate neuromuscular junction development

    Chengyong Shen, Lei Li ... Lin Mei
    A novel role of motoneuron Wnts in regulating presynaptic development at the neuromuscular junction.
    1. Neuroscience

    Astrocyte and L-lactate in the anterior cingulate cortex modulate schema memory and neuronal mitochondrial biogenesis

    Mastura Akter, Mahadi Hasan ... Ying Li
    Astrocytic Gi pathway activation in the anterior cingulate cortex impairs schema memory and neuronal mitochondrial biogenesis, which can be rescued by exogenous L-lactate administration directly into the area.

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