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    1. Cell Biology
    2. Developmental Biology

    Rediscovering the Rete Ovarii: a secreting auxiliary structure to the ovary

    Dilara N Anbarci, Jennifer McKey ... Blanche Capel
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Enalapril mitigates aging by targeting antioxidative genes via phosphorylated Smad1/5/9

    Wencong Lyu, Haochen Wang ... Wei Tao
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Cell Biology

    Glucokinase activity controls peripherally located subpopulations of β-cells that lead islet Ca2+ oscillations

    Erli Jin, Jennifer K Briggs ... Matthew J Merrins
    3D light-sheet imaging identifies the location and metabolic sensitivity of β-cell subpopulations that lead and coordinate islet Ca2+ oscillations.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    SERBP1 interacts with PARP1 and is present in PARylation-dependent protein complexes regulating splicing, cell division, and ribosome biogenesis

    Kira Breunig, Xuifen Lei ... Luiz O Penalva
    SERBP1 is associate with protein complexes regulating splicing, cell division, and ribosomal biogenesis that likely depend on G quadruplex (G4) binding and polyADP-ribosylation (PARylation) for their assembly and function.
    1. Neuroscience

    Brain areas for reversible symbolic reference, a potential singularity of the human brain

    Timo van Kerkoerle, Louise Pape ... Ghislaine Dehaene-Lambertz
    Humans spontaneously reverse learned associations while macaque monkeys do not, providing a minimal test of a distinctive human capacity for symbolic representations.
    1. Genetics and Genomics

    A molecular proximity sensor based on an engineered, dual-component guide RNA

    Junhong Choi, Wei Chen ... Jay Shendure
    In P3 editing, molecular interactions are sensed and converted directly into genome editing events, which may be useful for biological recording and synthetic molecular circuits deployed in living cells.
    1. Biochemistry and Chemical Biology

    Alzheimer-mutant γ-secretase complexes stall amyloid β-peptide production

    Parnian Arafi, Sujan Devkota ... Michael S Wolfe
    Further evidence in support of a new amyloid-independent hypothesis for the pathogenesis of Alzheimer's disease is provided, with an expanded set of Alzheimer-causing mutations in the protease that produces amyloid.
    Version of Record
    Research Article
    • Fundamental
    • Compelling
    • Convincing
    1. Computational and Systems Biology
    2. Medicine

    Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats

    Hong Yang, Cheng Zhang ... Adil Mardinoglu
    Inhibiting c-Jun N-terminal kinase exerts a cross-tissue therapeutic effect on metabolic dysfunction induced by sucrose overconsumption in rats.
    1. Developmental Biology

    Mechanical forces pattern endocardial Notch activation via mTORC2-PKC pathway

    Yunfei Mu, Shijia Hu ... Hongjun Shi
    A ligand independent mechanical sensitive mTORC2-PKC pathway activates Notch in the endocardium of the valve forming area.