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    1. Neuroscience

    Signal denoising through topographic modularity of neural circuits

    Barna Zajzon, David Dahmen ... Renato Duarte
    Topographic maps can gradually increase the fidelity of sensory representations and improve signal-to-noise ratio across multiple cortical circuits, a generic architectural feature that depends solely on the modularity of topographic projections and recurrent inhibition.
    1. Computational and Systems Biology
    2. Neuroscience

    Noise promotes independent control of gamma oscillations and grid firing within recurrent attractor networks

    Lukas Solanka, Mark CW van Rossum, Matthew F Nolan
    Random fluctuations in neuronal firing may enable a single brain region, the medial entorhinal cortex, to perform distinct roles in cognition (by generating gamma waves) and spatial navigation (by producing a grid cell map).
    1. Ecology
    2. Epidemiology and Global Health

    Physiology and ecology combine to determine host and vector importance for Ross River virus

    Morgan P Kain, Eloise B Skinner ... Erin A Mordecai
    The role host and vector species play in pathogen transmission cycles is best quantified by integrating species' physiological and ecological competence.
    1. Neuroscience

    The influence of evidence volatility on choice, reaction time and confidence in a perceptual decision

    Ariel Zylberberg, Christopher R Fetsch, Michael N Shadlen
    A single framework of bounded evidence accumulation resolves the seemingly paradoxical effects of noise on accuracy, reaction time and confidence.
    1. Evolutionary Biology

    Heterozygote advantage can explain the extraordinary diversity of immune genes

    Mattias Siljestam, Claus Rueffler
    An eco-evolutionary model shows that heterozygote advantage can maintain over 100 major histocompatibility complex alleles, providing a potent explanation for extraordinary immune gene diversity and challenges previous models that predicted limited allele coexistence.
    1. Physics of Living Systems

    Dynamics of cooperative excavation in ant and robot collectives

    S Ganga Prasath, Souvik Mandal ... L Mahadevan
    Observations of ant excavation from a confining corral, along with theoretical models and synthetic robot experiments show the emergence of cooperation induced by pheromones in a malleable environment that is moulded by and moulds collective behavior.
    1. Neuroscience

    Revealing unexpected complex encoding but simple decoding mechanisms in motor cortex via separating behaviorally relevant neural signals

    Yangang Li, Xinyun Zhu ... Yueming Wang
    Separating behaviorally relevant signals from irrelevant signals reveals that neural signals previously considered to contain little information encode rich information and suggests that linear readout may be performed in motor cortex.
    1. Neuroscience

    Conduction velocity along a key white matter tract is associated with autobiographical memory recall ability

    Ian A Clark, Siawoosh Mohammadi ... Eleanor A Maguire
    A new magnetic resonance brain imaging measure reveals that variations in people’s ability to recall their past experiences may be related to the speed at which electrical signals travel along axons in the parahippocampal cingulum bundle.
    1. Neuroscience

    Learning accurate path integration in ring attractor models of the head direction system

    Pantelis Vafidis, David Owald ... Richard Kempter
    A theoretical model combines self-supervised predictive learning with structural inductive biases to reveal how quasi-continuous attractors that perform accurate angular path integration can be learned from experience during development in the Drosophila and potentially other animal models.
    1. Computational and Systems Biology

    Patient-specific Boolean models of signalling networks guide personalised treatments

    Arnau Montagud, Jonas Béal ... Laurence Calzone
    Tailoring Boolean models to 488 prostate cancer patients and 8 cell lines data allows for the experimentally validated personalisation of drug treatments.