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    1. Medicine

    The generation of HepG2 transmitochondrial cybrids to reveal the role of mitochondrial genotype in idiosyncratic drug-induced liver injury

    Amy Louise Ball, Carol E Jolly ... Amy E Chadwick
    HepG2 transmitochondrial cybrids of haplogroup J genome had increased sensitivity to aspects of mitochondrial dysfunction induced by tolcapone and 2-hydroxyflutamide, compared to haplogroup H, thus cybrids provide a practical system to investigate the consequences of mitochondrial genome on drug-induced hepatotoxicity.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Livestock abortion surveillance in Tanzania reveals disease priorities and importance of timely collection of vaginal swab samples for attribution

    Felix Lankester, Tito J Kibona ... Sarah Cleaveland
    Livestock abortion surveillance can capture valuable information on important livestock pathogens, including those that are zoonotic and with epidemic potential, revealing importance of timely collection of diagnostic samples for attribution.
    1. Computational and Systems Biology
    2. Ecology

    The LOTUS initiative for open knowledge management in natural products research

    Adriano Rutz, Maria Sorokina ... Pierre-Marie Allard
    The LOTUS initiative builds, through the Wikidata knowledge graph, a virtuous cycle of data sharing practices for natural products research.
    1. Ecology
    2. Evolutionary Biology

    Signal categorization by foraging animals depends on ecological diversity

    David William Kikuchi, Anna Dornhaus ... Thomas N Sherratt
    In richer, more even communities, foragers form broad categories among their food resources that can select for convergence among signals, including mimetic resemblances.
    1. Computational and Systems Biology
    2. Medicine

    Development and evaluation of a machine learning-based in-hospital COVID-19 disease outcome predictor (CODOP): A multicontinental retrospective study

    Riku Klén, Disha Purohit ... David Gómez-Varela
    The generalizability of CODOP in distinct world regions and its flexibility to reckon with the changing availability of hospital resources makes it a clinically useful tool potentially improving the outcome prediction and the management of COVID-19 hospitalized patients.
    1. Epidemiology and Global Health

    Asymptomatic Bordetella pertussis infections in a longitudinal cohort of young African infants and their mothers

    Christopher J Gill, Christian E Gunning ... Pejman Rohani
    Longitudinal qPCR-based pertussis surveillance of a low-resource African cohort reveals frequent asymptomatic pertussis infections in both young infants and mothers and suggests possible early warning signals for epidemic outbreaks.
    1. Ecology

    Gaps in global wildlife trade monitoring leave amphibians vulnerable

    Alice C Hughes, Benjamin Michael Marshall, Colin T Strine
    Almost 98% of amphibian species have no regulation on their international trade, yet as 17% (1215 species) are in trade with 45% of individuals coming from the wild, including 445 Endangered/Data Deficient species, this poses a risk to species survival.
    1. Ecology

    The golden mimicry complex uses a wide spectrum of defence to deter a community of predators

    Stano Pekár, Lenka Petráková ... Marie E Herberstein
    A mimetic complex composed of at least 140 species of ants, wasps, spiders, true bugs and treehoppers, all with conspicuous golden bodies, has been discovered.
  1. Living Science: Watching jellyfish

    Eve Marder
    The natural world is more complex, and also more fragile, than it appears.
    1. Medicine
    2. Microbiology and Infectious Disease

    Combination of inflammatory and vascular markers in the febrile phase of dengue is associated with more severe outcomes

    Nguyen Lam Vuong, Phung Khanh Lam ... Sophie Yacoub
    Relationships of biomarkers with clinical outcome differed between children and adults and the best combinations associated with moderate/severe dengue comprised of six/seven vascular and immune biomarkers.