221 results found
    1. Cell Biology
    2. Chromosomes and Gene Expression

    The asymmetry of female meiosis reduces the frequency of inheritance of unpaired chromosomes

    Daniel B Cortes et al.
    Female meiotic spindles correct trisomy by expelling extra chromosomes into the first polar body.
    1. Physics of Living Systems
    2. Cell Biology

    Cortical flow aligns actin filaments to form a furrow

    Anne-Cecile Reymann et al.
    Compressing the actomyosin network by cortical flow causes filaments to align and form a constricting ring.
    1. Stem Cells and Regenerative Medicine

    Distinct SoxB1 networks are required for naïve and primed pluripotency

    Andrea Corsinotti et al.
    Genetic manipulations show that endogenous transcription factors of the SoxB1 class act redundantly to maintain primed pluripotency and reveal differential effects on transitions between pluripotent and differentiation states.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Polo-like kinase Cdc5 regulates Spc72 recruitment to spindle pole body in the methylotrophic yeast Ogataea polymorpha

    Hiromi Maekawa et al.
    Cdc5-dependent SPB regulation is linked to delayed cytoplasmic microtubule organization in Ogataea polymorpha.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Convergence of topological domain boundaries, insulators, and polytene interbands revealed by high-resolution mapping of chromatin contacts in the early Drosophila melanogaster embryo

    Michael R Stadler et al.
    Fruit fly chromosomes are divided into discrete structural domains by regions of decompacted chromatin, suggesting a novel model for the formation of a known class of genetic elements.
    1. Evolutionary Biology

    Moderate nucleotide diversity in the Atlantic herring is associated with a low mutation rate

    Chungang Feng et al.
    The Atlantic herring has the lowest mutation rate yet estimated in a vertebrate species and this partially explains its moderate nucleotide diversity given the large population size.
    1. Neuroscience

    Massive normalization of olfactory bulb output in mice with a 'monoclonal nose'

    Benjamin Roland et al.
    Inhibitory circuits in the olfactory bulb can amplify or suppress sensory inputs over a wide range of intensities to generate robust mitral cell output.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Systematic perturbation of retroviral LTRs reveals widespread long-range effects on human gene regulation

    Daniel R Fuentes et al.
    A new approach combines guide RNA multiplexing with CRISPR activation and interference to facilitate functional studies of transposable elements present in hundreds of copies throughout the human genome.
    1. Developmental Biology

    aPKC-mediated displacement and actomyosin-mediated retention polarize Miranda in Drosophila neuroblasts

    Matthew Robert Hannaford et al.
    The actomyosin network and phospho-regulation combine to polarize fate determinants at the Drosophila neuroblast cell cortex.
    1. Cell Biology
    2. Developmental Biology

    Cell volume changes contribute to epithelial morphogenesis in zebrafish Kupffer’s vesicle

    Agnik Dasgupta et al.
    During Kupffer's vesicle morphogenesis, cell volume anisotropy impacts cell shape changes.

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