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    1. Evolutionary Biology
    2. Neuroscience

    Metazoan evolution of glutamate receptors reveals unreported phylogenetic groups and divergent lineage-specific events

    David Ramos-Vicente, Jie Ji ... Àlex Bayés
    The animal phylogeny of glutamate receptors indicates that vertebrate types do not account for all receptor classes originated during evolution, neither are they the pinnacle of a linear evolutive process.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Ancient origins of arthropod moulting pathway components

    André Luiz de Oliveira, Andrew Calcino, Andreas Wanninger
    Evolutionary reconstruction of the ecdysis pathway shows that its major elements are present in the majority of metazoans, providing evidence that they originated much earlier than currently assumed.
    1. Evolutionary Biology

    Evolution of the gene regulatory network of body axis by enhancer hijacking in amphioxus

    Chenggang Shi, Shuang Chen ... Guang Li
    The gene regulatory network of Nodal signaling, underpinning body axes patterning, was evolved specifically in cephalochordate lineage.
    1. Developmental Biology
    2. Evolutionary Biology

    Single-cell RNA sequencing of the Strongylocentrotus purpuratus larva reveals the blueprint of major cell types and nervous system of a non-chordate deuterostome

    Periklis Paganos, Danila Voronov ... Maria Ina Arnone
    Reconstruction of cell-type families in the purple sea urchin larva reveals unprecedented transcriptional diversity, stunning neuronal complexity and a missing link to pancreas evolution, suggesting this approach can be also used to uncover hidden cell type homologies.
    1. Physics of Living Systems

    Reversal of contractility as a signature of self-organization in cytoskeletal bundles

    Martin Lenz
    Quantitative, experimentally testable predictions allow discrimination between contraction mechanisms in disordered actomyosin and microtubule/motor bundles.
    1. Developmental Biology
    2. Evolutionary Biology

    Development: Transforming a transcription factor

    Robert D Burke
    A transcription factor that regulates skeleton formation in sea urchin embryos has evolved a new domain that is essential for this process.
    Version of Record
    Insight
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Bacterial death and TRADD-N domains help define novel apoptosis and immunity mechanisms shared by prokaryotes and metazoans

    Gurmeet Kaur, Lakshminarayan M Iyer ... L Aravind
    Prokaryotic TRADD-N and Death-like adaptor domains in diverse predicted apoptosis and immune systems from multicellular prokaryotes and metazoans indicate the common origin of key apoptosis mechanisms required for the stabilization of multicellularity.
    1. Ecology
    2. Neuroscience

    Combined transcriptome and proteome profiling reveals specific molecular brain signatures for sex, maturation and circalunar clock phase

    Sven Schenk, Stephanie C Bannister ... Kristin Tessmar-Raible
    A molecular profiling approach to quantify transcripts and proteins from identical samples allows study of molecular effects of maturation, sexual differentiation and the endogenous circalunar clock in a marine worm.
    1. Developmental Biology
    2. Evolutionary Biology

    The Natural History of Model Organisms: Amphioxus as a model to study the evolution of development in chordates

    Salvatore D'Aniello, Stephanie Bertrand, Hector Escriva
    Interest in the ecology, biology and evolution of amphioxus is growing, and the availability of several species is helping to improve our understanding of chordate evolution.
    1. Cell Biology

    Actin assembly ruptures the nuclear envelope by prying the lamina away from nuclear pores and nuclear membranes in starfish oocytes

    Natalia Wesolowska, Ivan Avilov ... Peter Lenart
    Combined light and electron microscopy reveals a new function for Arp2/3-mediated actin assembly in nuclear envelope rupture, which leads to a separation of nuclear membranes and pores from the lamina.