113 results found
    1. Computational and Systems Biology
    2. Ecology

    Trade-off shapes diversity in eco-evolutionary dynamics

    Farnoush Farahpour, Mohammadkarim Saeedghalati ... Daniel Hoffmann
    In a minimalistic, generic model of competitive communities in which evolution is constrained by life-history trade-offs, stable biodiversity emerges with species adapted to different functional niches.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Eco-evolutionary dynamics of clonal multicellular life cycles

    Vanessa Ress, Arne Traulsen, Yuriy Pichugin
    The evolution of clonal multicellular life cycles, whose growth is constrained by competition, may lead to coexistence or multistability between several life cycles while evolutionarily stable strategies can be inferred from the analysis of a model with unconstrained growth.
    1. Ecology
    2. Evolutionary Biology

    Interactions between strains govern the eco-evolutionary dynamics of microbial communities

    Akshit Goyal, Leonora S Bittleston ... Otto X Cordero
    Rapidly diversifying biotic interactions decouple the dynamics of nearly identical strains.
    1. Ecology

    Synthetic eco-evolutionary dynamics in simple molecular environment

    Luca Casiraghi, Francesco Mambretti ... Tommaso Bellini
    A variant of SELEX introduced here to induce abiotic evolution in a molecular system enables to observe and study speciation, the nature of fitness, and the interplay between use of resources and interactions between individuals.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Eco-evolutionary dynamics of adapting pathogens and host immunity

    Pierre Barrat-Charlaix, Richard A Neher
    Diverse histories of viral exposure, for example in individuals of different age, makes viral evolution less predictable with features of adaptive and neutral evolution.
    1. Evolutionary Biology

    Heterozygote advantage can explain the extraordinary diversity of immune genes

    Mattias Siljestam, Claus Rueffler
    An eco-evolutionary model shows that heterozygote advantage can maintain over 100 major histocompatibility complex alleles, providing a potent explanation for extraordinary immune gene diversity and challenges previous models that predicted limited allele coexistence.
    1. Ecology
    2. Evolutionary Biology

    Novel pathogen introduction triggers rapid evolution in animal social movement strategies

    Pratik Rajan Gupte, Gregory F Albery ... Franz J Weissing
    The introduction of infectious pathogens to a simulated animal population leads to rapid evolutionary transitions in how individuals move in a social context, with distinct movement morphs evolved that make trade-offs between sociality and infection risk.
    1. Evolutionary Biology
    2. Medicine

    Evolution-based mathematical models significantly prolong response to abiraterone in metastatic castrate-resistant prostate cancer and identify strategies to further improve outcomes

    Jingsong Zhang, Jessica Cunningham ... Robert Gatenby
    Integration of evolutionary dynamics framed through a mathematical model improved outcomes in abiraterone monotherapy for the treatment of metastatic castrate-resistant prostate cancer.
    1. Computational and Systems Biology

    Ecological feedback in quorum-sensing microbial populations can induce heterogeneous production of autoinducers

    Matthias Bauer, Johannes Knebel ... Erwin Frey
    Quorum sensing enables heterogeneous production of autoinducers in microbial populations, suggesting an alternative mechanism to stochastic gene expression in bistable gene-regulatory circuits to control phenotypic heterogeneity.
    1. Ecology
    2. Evolutionary Biology

    Why is cyclic dominance so rare?

    Hye Jin Park, Yuriy Pichugin, Arne Traulsen
    A mathematical model for a popular biological diversity mechanism, cyclic dominance, is more likely to emerge by assembly than by evolutionary diversification, which rationalizes why few empirically studies find it.

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