4,384 results found
    1. Genetics and Genomics

    The genetic basis for ecological adaptation of the Atlantic herring revealed by genome sequencing

    Alvaro Martinez Barrio et al.
    Whole genome sequencing of 19 populations of Atlantic and Baltic herring reveals hundreds of individual loci underlying adaptation to a low salinity niche or timing of reproduction.
    1. Evolutionary Biology

    Adaptive substitutions underlying cardiac glycoside insensitivity in insects exhibit epistasis in vivo

    Andrew M Taverner et al.
    Genome engineering and phenotyping in vivo reveal surprising new features of adaptive amino acid substitutions that were previously inaccessible.
    1. Cell Biology

    The copy-number and varied strengths of MELT motifs in Spc105 balance the strength and responsiveness of the spindle assembly checkpoint

    Babhrubahan Roy et al.
    Cell biological and genetic analyses reveal how budding yeast cells optimize Spindle Assembly checkpoint signaling to maximize chromosome segregation accuracy and minimize unnecessary delays in anaphase onset.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Genetic analysis reveals functions of atypical polyubiquitin chains

    Fernando Meza Gutierrez et al.
    A comprehensive genetic interaction screen uncovered biological roles of K11 linkages in amino acid homeostasis and cell cycle regulation in yeast.
    1. Microbiology and Infectious Disease

    Pirating conserved phage mechanisms promotes promiscuous staphylococcal pathogenicity island transfer

    Janine Bowring et al.
    Structural and genetic analyses reveal the highly evolved and unprecedented biological strategy used by SaPIs to spread in nature.
    1. Cell Biology

    Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans

    Yanan Sun et al.
    Cell biological and genetic studies reveal age-associated alterations of lysosomes and modulation of lysosomal activity by longevity pathways.
    1. Cell Biology
    2. Evolutionary Biology

    Phylogenetic divergence of cell biological features

    Michael Lynch
    Cell biological features are subject to stochastic forces of mutation and random genetic drift, which together cause lineages exposed to identical selection pressures to diverge, and mean phenotypes to deviate from expectations under optimizing selection.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Nuclear genetic regulation of the human mitochondrial transcriptome

    Aminah T Ali et al.
    Common nuclear genetic variants are associated with fundamental biological processes occurring in human mitochondria and potentially point to novel roles for nuclear genes in transcriptional regulation of the mitochondrial genome.
    1. Microbiology and Infectious Disease

    Contact-dependent killing by Caulobacter crescentus via cell surface-associated, glycine zipper proteins

    Leonor García-Bayona et al.
    Genetic, biochemical, and cell biological approaches reveal a new form of contact-dependent inhibition in bacteria involving bacteriocin-like proteins that aggregate on the surface of cells.

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