A novel mathematical modeling framework for antibiotic-resistant bacteria combining within-host microbiome-pathogen interactions with population-level pathogen epidemiology, demonstrating how antibiotic consumption and ecological competition come together to drive the spread of resistance.
Megan Ann Supple, Jason G Bragg ... Justin O Borevitz
Empirical patterns of genomic and phenotypic variation across the landscape are used to develop a predictive model that will help build resilient ecological communities.
A novel computation tool for microbial community modeling predicts the evolution and diversification of E. coli in laboratory evolution experiments and gives insight into the underlying metabolic processes.
A trait-based model of dryland vegetation uncovers the roles of spatial self-organization in maintaining biodiversity in a changing climate and offers novel ways of managing ecosystems at risk.
Longstanding eco-evolutionary theories are tested using shotgun metagenomic data from the human gut microbiome, showing links between community diversity and the evolutionary trajectory of a focal species within the community.
The multi-stage model of carcinogenesis requires the incorporation of aging-dependent somatic selection and life history-dependent evolution of species-specific tumor suppressor mechanisms in order to generalize carcinogenesis across tissues and species.
