387 results found
    1. Cell Biology
    2. Plant Biology

    From plasmodesma geometry to effective symplasmic permeability through biophysical modelling

    Eva E Deinum et al.
    A new biophysical model enables the reconciliation of ultrastructural and tissue level measurements on parameters affecting intercellular communication, and provides novel functional insight into experimental findings.
    1. Cell Biology
    2. Computational and Systems Biology

    Development, calibration, and validation of a novel human ventricular myocyte model in health, disease, and drug block

    Jakub Tomek et al.
    A computer model of human cardiomyocyte was produced and validated on independent datasets, overcoming shortcomings of its predecessors, also yielding broadly relevant insights and results on major ionic currents.
    1. Cell Biology

    Reduction of elevated proton leak rejuvenates mitochondria in the aged cardiomyocyte

    Huiliang Zhang et al.
    The primary respiratory defect seen in aged cardiomyocytes is an elevated proton leak mediated by ANT1, and this is prevented by treatment with SS-31 (elamipretide).
    1. Microbiology and Infectious Disease
    2. Cell Biology

    The Plasmodium falciparum rhoptry protein RhopH3 plays essential roles in host cell invasion and nutrient uptake

    Emma S Sherling et al.
    The rhoptry protein RhopH3 is crucial for the invasion and growth of the malaria parasite and disruption of it provides insight into the binding of the parasite to the host red blood cell and into the formation of new import pathways.
    1. Cell Biology

    Age-dependent deterioration of nuclear pore assembly in mitotic cells decreases transport dynamics

    Irina L Rempel et al.
    In replicative ageing yeast cells, an age-dependent impediment in proper assembly of nuclear pore complexes is associated with altered nuclear transport.
    1. Physics of Living Systems
    2. Neuroscience

    Physical limits to magnetogenetics

    Markus Meister
    Recent reports on the ability of biological molecules to sense magnetic fields are found to be inconsistent with basic physical principles.
    1. Cell Biology

    Apolipoprotein L-1 renal risk variants form active channels at the plasma membrane driving cytotoxicity

    Joseph A Giovinazzo et al.
    Cytotoxicity associated with APOL1 renal-risk variants occurs through its plasma-membrane localization, where aberrant channel activity drives a sustained sodium and calcium influx leading to cell swelling and eventually cell death.
    1. Cancer Biology
    2. Cell Biology

    The ESRP1-GPR137 axis contributes to intestinal pathogenesis

    Lukas Franz Mager et al.
    ESRP1 is central to intestinal barrier integrity in mice and humans and alterations in ESRP1 function or expression contribute to intestinal pathology, partly through modified expression of ESRP1-specific GPR137 isoforms.
    1. Physics of Living Systems

    Extracellular matrix in multicellular aggregates acts as a pressure sensor controlling cell proliferation and motility

    Monika E Dolega et al.
    Theoretical predictions and experiments on multicellular aggregates indicate that the extracellular matrix acts as a mechanical sensor, which regulates cell proliferation and migration in a three-dimensional environment.
    1. Cell Biology
    2. Physics of Living Systems

    Centering and symmetry breaking in confined contracting actomyosin networks

    Niv Ierushalmi et al.
    Novel mechanisms for cellular centering and symmetry breaking involving persistent contractile actomyosin flows and their hydrodynamic interactions with the fluid cytosol are presented and studied using a minimal, reconstituted system.

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