2,119 results found
    1. Immunology and Inflammation

    A CD4+ T cell reference map delineates subtype-specific adaptation during acute and chronic viral infections

    Massimo Andreatta, Ariel Tjitropranoto ... Santiago J Carmona
    Description of the transcriptional and clonal landscape of virus-specific CD4+ T cells in acute and chronic viral infections, and a new reference map to interpret CD4 T cell diversity across tissues and biological models.
    1. Plant Biology

    Multiple pairs of allelic MLA immune receptor-powdery mildew AVRA effectors argue for a direct recognition mechanism

    Isabel ML Saur, Saskia Bauer ... Paul Schulze-Lefert
    Allelic MLA immune receptors have an exceptional propensity to directly detect sequence-unrelated pathogen effectors and this feature might have facilitated functional diversification of the receptor in the host population.
    1. Developmental Biology

    The Hippo pathway effector YAP is an essential regulator of ductal progenitor patterning in the mouse submandibular gland

    Aleksander D Szymaniak, Rongjuan Mi ... Xaralabos Varelas
    The transcriptional regulator YAP directs the specification and differentiation of stem cells that give rise to salivary gland ductal epithelium.
    1. Neuroscience

    The landscape of regulatory genes in brain-wide neuronal phenotypes of a vertebrate brain

    Hui Zhang, Haifang Wang ... Jie He
    Single-cell transcriptomes of larval zebrafish whole brain shed light on the multidimensional landscapes of transcription factors and post-transcriptional regulators in vertebrate whole-brain neuronal classification and revealed principles of how neuronal cell diversity develops and evolves.
    1. Plant Biology

    Pathogen effectors and plant immunity determine specialization of the blast fungus to rice subspecies

    Jingjing Liao, Huichuan Huang ... Jean-Benoit Morel
    Specialized fungal pathogen populations infect rice varieties with contrasting immune systems co-cultivated in a traditional agro-system, indicating the relevance of crop diversity to restricting epidemics in the landscape.
    1. Immunology and Inflammation

    The transcription factor Bach2 negatively regulates murine natural killer cell maturation and function

    Shasha Li, Michael D Bern ... Wayne M Yokoyama
    Deficiency of the transcriptional repressor, Bach2, results in more mature mouse natural killer cells.
    1. Immunology and Inflammation

    Nuclear receptor corepressor 1 controls regulatory T cell subset differentiation and effector function

    Valentina Stolz, Rafael de Freitas e Silva ... Wilfried Ellmeier
    The transcriptional adapter protein NCOR1 that links chromatin-modifying enzymes with gene-specific transcription factors controls naive and effector regulatory T cell states.
    1. Genetics and Genomics

    Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors

    Joseph M Replogle, Jessica L Bonnar ... Marco Jost
    Newly developed, highly active CRISPR interference single guide RNA libraries and effectors together enable high-quality genetic screens across cell models.
    1. Microbiology and Infectious Disease

    A framework for community curation of interspecies interactions literature

    Alayne Cuzick, James Seager ... Kim E Hammond-Kosack
    A framework has been devised that enables global participation in the curation of publications on any topic involving two or more living organisms, ranging from microscopic to larger sizes, in their natural or artificial environments or ecosystems.
    1. Cell Biology
    2. Immunology and Inflammation

    Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions

    Alejandro Villarino, Arian Laurence ... John J O'Shea
    Asymmetrical expression dictates functional dominance of one STAT5 paralog at cellular and tissue levels despite redundancy at molecular and genomic levels.

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