1,802 results found
    1. Structural Biology and Molecular Biophysics

    An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump

    Zhao Wang et al.
    The tripartite drug efflux pump AcrA-AcrB-TolC, representative of a wide group of pumps from Gram-negative bacteria, enters a transport-competent state through long-distance conformational changes that switch the channel from a closed to an open state.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB

    Thomas Eicher et al.
    A transport mechanism is uncovered in the major drug-efflux system in E. coli involving two remote alternating-access conformational cycles, which could provide the basis for the development of allosteric inhibitors against multidrug resistance.
    1. Immunology and Inflammation

    Na+ influx via Orai1 inhibits intracellular ATP-induced mTORC2 signaling to disrupt CD4 T cell gene expression and differentiation

    Yong Miao et al.
    Non-specific sodium entry inhibits T cell receptor induced gene expression and differentiation of T cells by depleting intracellular ATP and disrupting mTORC2 dependent signalling axis.
    1. Neuroscience

    Magnesium efflux from Drosophila Kenyon cells is critical for normal and diet-enhanced long-term memory

    Yanying Wu et al.
    Regulated neuronal magnesium efflux is a critical element of normal and magnesium-enhanced memory.
    1. Structural Biology and Molecular Biophysics

    The molecular basis for an allosteric inhibition of K+-flux gating in K2P channels

    Susanne Rinné et al.
    A combined systematic alanine scanning and molecular modelling approach reveals the molecular basis for an allosteric inhibition mechanism of K+-flux gating in K2P channels.
    1. Neuroscience

    Impaired ABCA1/ABCG1-mediated lipid efflux in the mouse retinal pigment epithelium (RPE) leads to retinal degeneration

    Federica Storti et al.
    Lipid efflux by the retinal pigment epithelium is crucial for proper retinal integrity and function, and its impairment may contribute to diseases like age-related macular degeneration.
    1. Plant Biology

    Auxin efflux by PIN-FORMED proteins is activated by two different protein kinases, D6 PROTEIN KINASE and PINOID

    Melina Zourelidou et al.
    Two protein kinases are required to activate auxin efflux transporters from plants.
    1. Neuroscience

    Dendritic osmosensors modulate activity-induced calcium influx in oxytocinergic magnocellular neurons of the mouse PVN

    Wanhui Sheng et al.
    Activity-induced dendritic calcium influx in oxytocinergic magnocellular neurons can be robustly modulated by a highly diverse set of stimuli acting on distinct types of ion channels expressed along the dendritic membrane.
    1. Cell Biology
    2. Immunology and Inflammation

    Calcium influx through CRAC channels controls actin organization and dynamics at the immune synapse

    Catherine A Hartzell et al.
    By restricting actin polymerization to the perimeter of the immune synapse and promoting depolymerization, calcium influx drives centripetal actin flow, which confines CRAC channels and the endoplasmic reticulum to the synapse center.
    1. Neuroscience

    Neuronal processing of noxious thermal stimuli mediated by dendritic Ca2+ influx in Drosophila somatosensory neurons

    Shin-Ichiro Terada et al.
    Drosophila polymodal nociceptors use precipitous fluctuation of the firing rate, which depends on Ca2+ influx, as a key signal encoding a heat sensation and evoking the robust heat avoidance behavior.

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