2,617 results found
    1. Computational and Systems Biology
    2. Biochemistry and Chemical Biology

    Dissection of affinity captured LINE-1 macromolecular complexes

    Martin S Taylor et al.
    The range of molecular forms adopted by L1 retrotransposons reflect a tapestry of lifecycle-permissive and -restrictive host-parasite interactions occurring within cells.
    1. Genes and Chromosomes
    2. Immunology and Inflammation

    Gene-specific mechanisms direct glucocorticoid-receptor-driven repression of inflammatory response genes in macrophages

    Maria A Sacta et al.
    A comprehensive analysis of the glucocorticoid-sensitive pro-inflammatory genes in macrophages reveals fundamental differences between the temporal events and components of transcriptional machinery that the glucocorticoid receptor targets to repress their transcription.
    1. Cancer Biology
    2. Immunology and Inflammation

    Tumor initiating cells induce Cxcr4-mediated infiltration of pro-tumoral macrophages into the brain

    Kelda Chia et al.
    Pre-neoplastic cells in the brain release SDF1, which mediates an immediate infiltration of macrophages that differentiate into microglia-like cells and promote proliferation of pre-neoplastic cells.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Translational control of ERK signaling through miRNA/4EHP-directed silencing

    Seyed Mehdi Jafarnejad et al.
    ERK/MAPK activity is regulated by the cap-binding protein 4EHP, via translational control of the DUSP6 phosphatase.
    1. Biochemistry and Chemical Biology
    2. Biophysics and Structural Biology

    3.3-Å resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound

    Edward J Brignole et al.
    Cryo-electron microscopy structures of human ribonucleotide reductase reveal molecular details of substrate selection and allosteric inhibition through assembly of its large subunit into a ring that excludes its small subunit.
    1. Ecology

    Implications of being born late in the active season for growth, fattening, torpor use, winter survival and fecundity

    Britta Mahlert et al.
    Being born late in the active season is associated with a fast life history in a hibernating species, the garden dormouse (Eliomys quercinus).
    1. Genes and Chromosomes

    Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres

    Juan Manuel Povedano et al.
    Telomerase gene therapy represents a novel effective treatment for pulmonary fibrosis associated with short telomeres by improving pulmonary function, decreasing inflammation and accelerating fiber disappearance in fibrotic lungs.
    1. Neuroscience

    The modulation of neural gain facilitates a transition between functional segregation and integration in the brain

    James M Shine et al.
    The flexible network architecture of the brain is sensitive to the modulation of neural gain, which may be mediated by ascending arousal nuclei, such as the noradrenergic locus coeruleus.
    1. Developmental Biology and Stem Cells

    Spatially resolved RNA-sequencing of the embryonic heart identifies a role for Wnt/β-catenin signaling in autonomic control of heart rate

    Silja Barbara Burkhard, Jeroen Bakkers
    A genome wide transcriptome dataset of the embryonic zebrafish heart with high spatial resolution was established and used to identify a novel mechanism regulating pacemaker function.
    1. Cell Biology
    2. Plant Biology

    Stromule extension along microtubules coordinated with actin-mediated anchoring guides perinuclear chloroplast movement during innate immunity

    Amutha Sampath Kumar et al.
    Stromules induced during plant innate immunity dynamically interact and use the cytoskeleton to form and to direct the movement of chloroplasts.

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