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    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair

    Shintaro Ide, Yoshihiko Kobayashi ... Tomokazu Souma
    Ferroptotic stress enhances the accumulation of damage-associated inflammatory proximal tubular cell state, thereby promoting maladaptive renal repair and the AKI-to-CKD transition.
    1. Neuroscience

    Activity dynamics of amygdala GABAergic neurons during cataplexy of narcolepsy

    Ying Sun, Carlos Blanco-Centurion ... Meng Liu
    Deep brain calcium imaging reveals the abnormal neuronal activity patterns of the amygdala GABAergic neurons in an animal model of human sleep disorder narcolepsy.
    1. Neuroscience

    Circulating transforming growth factor-β1 facilitates remyelination in the adult central nervous system

    Machika Hamaguchi, Rieko Muramatsu ... Toshihide Yamashita
    Although central nervous system (CNS) regeneration has been considered to be controlled by CNS microenvironment, CNS injury causes leading to leakage of circulating factors into CNS, which promotes CNS regeneration.
    1. Cell Biology

    Tumor elimination by clustered microRNAs miR-306 and miR-79 via noncanonical activation of JNK signaling

    Zhaowei Wang, Xiaoling Xia ... Tatsushi Igaki
    miR-306 and miR-79 selectively eliminate JNK-activated tumors, providing a new microRNA-based strategy against cancer.
    1. Neuroscience

    Neural circuit mechanisms for transforming learned olfactory valences into wind-oriented movement

    Yoshinori Aso, Daichi Yamada ... Toshihide Hige
    A cluster of neurons that integrates inhibitory and excitatory synaptic inputs from the mushroom body output neurons of the appetitive and aversive memory compartments, respectively, triggers upwind steering, mediating memory-driven olfactory navigation behaviors.
    1. Neuroscience

    Primate amygdala neurons evaluate the progress of self-defined economic choice sequences

    Fabian Grabenhorst, Istvan Hernadi, Wolfram Schultz
    Neurons in the amygdala, a brain system usually associated with emotion, track progress during sequential reward-directed choices according to an internal plan in Rhesus macaques.
    1. Developmental Biology
    2. Microbiology and Infectious Disease

    Identification of key yeast species and microbe–microbe interactions impacting larval growth of Drosophila in the wild

    Ayumi Mure, Yuki Sugiura ... Yukako Hattori
    The growth of wild Drosophila larvae on fruits is promoted by a yeast releasing essential nutrients extracellularly or by a stable association with a nutrient-providing bacterium established by microbe–microbe interactions.
    1. Cancer Biology
    2. Immunology and Inflammation

    Tissue-resident natural killer cells support survival in pancreatic cancer through promotion of cDC1-CD8 T activity

    Simei Go, Constantinos Demetriou ... Eric O Neill
    Tissue-resident natural killer cells are important mediators of CD8 T responses in human cancers and these cells can be harnessed to increase immunity against pancreatic ductal adenocarcinoma.
    1. Developmental Biology

    Wnt11 acts on dermomyotome cells to guide epaxial myotome morphogenesis

    Ann Kathrin Heilig, Ryohei Nakamura ... Toru Kawanishi
    A medaka mutant revealed that Wnt11 promotes formation of uniquely large protrusions from non-myogenic dorsal dermomyotome cells, which guide the epaxial myotome dorsally to achieve the coverage of the neural tube.
    1. Neuroscience

    Neurobehavioral evidence of interoceptive sensitivity in early infancy

    Lara Maister, Teresa Tang, Manos Tsakiris
    Pre-verbal infants demonstrate an implicit sensitivity to interoceptive sensations, which fluctuates spontaneously during emotional processing and guides audiovisual preferences in the environment.