25 results found
  1. Episode 44: January 2018

    In this episode, we hear about self-esteem, a new genus of extinct horse, the future of biological engineering, mosquito trackers, and sperm competition in salmon.
    1. Developmental Biology

    Oviductal estrogen receptor α signaling prevents protease-mediated embryo death

    Wipawee Winuthayanon et al.
    Cyclic estrogen signaling in oviduct epithelial cells suppresses oviduct luminal protease activity to allow survival and development of preimplantation embryos
    1. Ecology

    Experimental investigation of ant traffic under crowded conditions

    Laure-Anne Poissonnier et al.
    Behavioral experiments reveal that ants, contrary to humans, avoid the formation of traffic jams at extreme density.
    1. Computational and Systems Biology

    Emergence and propagation of epistasis in metabolic networks

    Sergey Kryazhimskiy
    Mutations that affect a metabolic network generically exhibit epistasis, which propagates to higher level phenotypes, such as fitness, carrying some information about the network’s topology.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A molecular tweezer antagonizes seminal amyloids and HIV infection

    Edina Lump et al.
    CLR01 is a small molecule that could be an effective topical microbicide to eliminate HIV (and other enveloped viruses), and to antagonize host-encoded amyloid fibrils that promote HIV infection.
    1. Cancer Biology

    KLK3/PSA and cathepsin D activate VEGF-C and VEGF-D

    Sawan Kumar Jha et al.
    Both VEGF-C and VEGF-D can be activated by KLK3/PSA and Cathepsin D, producing two novel VEGF-C forms and the known VEGFR-2-specific form of VEGF-D.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Slo1 is the principal potassium channel of human spermatozoa

    Nadja Mannowetz et al.
    Potassium ions enter and leave human sperm cells via a calcium-dependent ion channel that is also pH-independent.
    1. Ecology
    2. Neuroscience

    BiteOscope, an open platform to study mosquito biting behavior

    Felix JH Hol et al.
    A new tool to visualize blood-feeding mosquitoes in high resolution and quantitatively characterize their behavior sheds light on contact-dependent sensing and blood-feeding dynamics of several medically relevant mosquito species.
    1. Evolutionary Biology
    2. Genetics and Genomics

    A common 1.6 mb Y-chromosomal inversion predisposes to subsequent deletions and severe spermatogenic failure in humans

    Pille Hallast et al.
    In addition to its academic merits, characterizing the genetic determinants of male (in)fertility and identifying clinically actionable genetic variants can lead to improved diagnosis or even treatment of such conditions.
    1. Cell Biology
    2. Developmental Biology

    TMEM95 is a sperm membrane protein essential for mammalian fertilization

    Ismael Lamas-Toranzo et al.
    TMEM95, a protein localized to the sperm acrosome cap, is essential for fertilization.

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