476 results found
    1. Structural Biology and Molecular Biophysics

    Handling of intracellular K+ determines voltage dependence of plasmalemmal monoamine transporter function

    Shreyas Bhat et al.
    Subtle differences in handling of intracellular cations can drive macroscopic functional differences in structurally similar monoamine transporters.
    1. Structural Biology and Molecular Biophysics

    Voltage-clamp fluorometry analysis of structural rearrangements of ATP-gated channel P2X2 upon hyperpolarization

    Rizki Tsari Andriani, Yoshihiro Kubo
    A fluorometric analysis under voltage clamp shows the presence of a converged electric field in P2X2 channel with no canonical voltage-sensor and identifies the structural determinants for the voltage-dependent gating.
    1. Neuroscience

    Introduction to the EQIPD quality system

    Anton Bespalov et al.
    A system has been developed that supports generation of reliable basic biomedical research data while being open-access and lean with no negative impact on freedom of scientific exploration.
    1. Neuroscience

    Metal microdrive and head cap system for silicon probe recovery in freely moving rodent

    Mihály Vöröslakos et al.
    A reusable system of 3D printed stainless steel microdrive and plastic head cap allows stable recording of electrophysiological data in mice and rats and easy recovery of silicon probes.
    1. Structural Biology and Molecular Biophysics

    Distinct expression requirements and rescue strategies for BEST1 loss- and gain-of-function mutations

    Qingqing Zhao et al.
    BEST1 autosomal dominant loss-of-function mutations surprisingly behave in a dominant-negative manner, whereas gain-of-function mutations exhibit a strong dominant effect that necessitates CRISPR/Cas9-mediated suppression of the endogenous mutant allele in gene therapy.
    1. Medicine

    Miniaturized 3D bone marrow tissue model to assess response to Thrombopoietin-receptor agonists in patients

    Christian A Di Buduo et al.
    A 3D bone marrow niche that reproduces megakaryocyte differentiation and ex vivo platelet production from hematopoietic progenitors and iPSCs of thrombocytopenic patients predicts individual response to Eltrombopag accurately.
    1. Medicine
    2. Neuroscience

    Recovery of consciousness and cognition after general anesthesia in humans

    George A Mashour et al.
    Cognitive reconstitution after pharmacologic unconsciousness is an extended process, executive function is more robust than expected, and the healthy human brain is resilient to the effects of deep general anesthesia.
    1. Medicine

    Development and validation of a nomogram to better predict hypertension based on a 10-year retrospective cohort study in China

    Xinna Deng et al.
    A developed and validated nomogram better predicts the risk of hypertension based on a 10-year retrospective cohort study in China.
    1. Neuroscience

    Distinct protocerebral neuropils associated with attractive and aversive female-produced odorants in the male moth brain

    Jonas Hansen Kymre et al.
    Electrophysiological and morphological identification of individual pheromone projection neurons in male moth reveals a coding system for optimizing mate search strategy, including computation of three female-produced signals in distinct protocerebral regions.
    1. Computational and Systems Biology
    2. Medicine

    Computational modeling identifies embolic stroke of undetermined source patients with potential arrhythmic substrate

    Savannah F Bifulco et al.
    In models reconstructed from MRI scans of patients with embolic stroke of undetermined source, computational simulations reveal that fibrosis has the intrinsic capacity to sustain arrhythmia drivers when subjected to triggered activity known to exist in patients with atrial fibrillation.

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