Browse the search results

Page 2 of 48
    1. Neuroscience

    Neuronal morphologies built for reliable physiology in a rhythmic motor circuit

    Adriane G Otopalik et al.
    Neurite geometry enables expansive and highly-branched neuronal structures to operate like single electrical compartments and simple linear integrators.
    1. Biochemistry and Chemical Biology

    A two-lane mechanism for selective biological ammonium transport

    Gordon Williamson et al.
    A new cellular transport mechanism splits the substrate and separately translocates its fragments to achieve selectivity.
  1. Point of View: Improving on legacy conferences by moving online

    Titipat Achakulvisut et al.
    Neuromatch was an online conference that attracted around 3000 participants and offered most of the benefits of traditional conferences.
    1. Neuroscience

    Functional MRI: Making connections in the brain

    Alex TL Leong, Ed X Wu
    Simultaneous measurements of neuronal activity and fMRI signals in the rat brain have shed new light on the origins of resting-state fMRI connectivity networks.
    Insight
    Available as:
    • HTML
    • PDF
    1. Neuroscience

    Preserving inhibition with a disinhibitory microcircuit in the retina

    Qiang Chen et al.
    A disinhibitory motif in the retina mediates noise resilience of motion detection using an inverted algorithm of disinhibition due to the interplay between network activity and synaptic plasticity.
    1. Genetics and Genomics
    2. Medicine

    Effects of lifelong testosterone exposure on health and disease using Mendelian randomization

    Pedrum Mohammadi-Shemirani et al.
    Long-term increased testosterone improved body composition and bone density, but lowered HDL and raised risks of hypertension, androgenic alopecia, prostate cancer, and spinal stenosis in males.
    1. Neuroscience

    Localized inhibition in the Drosophila mushroom body

    Hoger Amin et al.
    A large interneuron in the Drosophila mushroom body has compartmentalized activity, which causes localized inhibition and predicts that Kenyon cells inhibit themselves more than they inhibit other individual Kenyon cells.
    1. Structural Biology and Molecular Biophysics

    Patient-specific mutations impair BESTROPHIN1’s essential role in mediating Ca2+-dependent Cl- currents in human RPE

    Yao Li et al.
    A multidisciplinary platform featured by patient-derived RPEs is established to study the disease-causing mechanisms of BEST1 mutations, and demonstrates gene-supplemented rescue of the mutation-caused deficiency in Ca2+-dependent Cl- current in human RPE.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    The Ca2+ transient as a feedback sensor controlling cardiomyocyte ionic conductances in mouse populations

    Colin M Rees et al.
    Feedback sensing of the intracellular calcium concentration suffices to reproduce the diversity of ionic conductances underlying normal cardiac electromechanical function in a genetically diverse population of mice.
    1. Medicine
    2. Neuroscience

    Aberrant subchondral osteoblastic metabolism modifies NaV1.8 for osteoarthritis

    Jianxi Zhu et al.
    Osteoblastic PGE2 induces pain and OA progression by NaV1.8 modification and serves as a potential target multiple skeletal pain and degenerations.