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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The structure of the COPII transport-vesicle coat assembled on membranes

    Giulia Zanetti et al.
    A structure of the complete, membrane bound, COPII coat solved by sub-tomogram averaging reveals the arrangement of all protein subunits on the membrane and suggests a mechanism for coating heterogeneously-shaped carriers.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    The presence and absence of periplasmic rings in bacterial flagellar motors correlates with stator type

    Mohammed Kaplan et al.
    A correlation between the periplasmic embellishment of the flagellar motor and its stator system type is described, motors with dual H+-dependent stator systems have one periplasmic ring formed by MotY.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    CryoEM structures of membrane pore and prepore complex reveal cytolytic mechanism of Pneumolysin

    Katharina van Pee et al.
    The near-atomic cryoEM pore complex structure of pneumolysin, the main virulence factor of Streptococcus pneumoniae, shows how the individual domains rearrange during the pore formation.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    In situ structural analysis of the Yersinia enterocolitica injectisome

    Mikhail Kudryashev et al.
    The basal body of the type-III secretion system of Yersinia enterocolitica within bacterial membranes shows elasticity and is longer than related isolated systems.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The role of Cdc42 and Gic1 in the regulation of septin filament formation and dissociation

    Yashar Sadian et al.
    Imaging with electron microscopy and cryo-electron tomography reveals that competition between Cdc42 and Gic1 for the same subunit within septins controls the formation and breakdown of septin filaments.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Membrane bridging by Munc13-1 is crucial for neurotransmitter release

    Bradley Quade et al.
    Cryo-electron tomography, reconstitution, and electrophysiological data show that a fundamental function of Munc13-1 is to bridge synaptic vesicles to the presynaptic plasma membrane.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    A mitofusin-dependent docking ring complex triggers mitochondrial fusion in vitro

    Tobias Brandt et al.
    A combination of an in vitro mitochondrial fusion assay with electron cryo-tomography (cryo-ET) reveals distinct steps and protein complexes during mitofusin-dependent fusion between adjacent mitochondrial outer membranes.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM: Protein complexes in focus

    Robert M Glaeser
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    1. Cell Biology
    2. Computational and Systems Biology

    Science Forum: The Human Cell Atlas

    Aviv Regev et al.
    Advances in techniques for analysing single cells and tissues have inspired an international effort to create comprehensive reference maps of all human cells - the fundamental units of life - as a basis for both understanding human health and diagnosing, monitoring and treating disease.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Cutting Edge: Building bridges between cellular and molecular structural biology

    Ardan Patwardhan et al.
    The integration of structural data from different imaging scales requires the development of standards and tools for representing the segmentation and transformation of data, and for the annotation of biological structures.