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29 results found
    1. Structural Biology and Molecular Biophysics

    Structures of translationally inactive mammalian ribosomes

    Alan Brown et al.
    Mining electron cryomicroscopy data reveals new ribosomal interactions that preclude translation to potentially regulate gene expression.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Structural principles of SNARE complex recognition by the AAA+ protein NSF

    K Ian White et al.
    Electron-cryomicroscopy structures of the supercomplex of NSF, αSNAP, and neuronal SNAREs in the presence of ATP under non-hydrolyzing conditions at 3.9 Å resolution reveal interactions between the N-terminal residues of SNAP-25 and NSF.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure of a AAA+ unfoldase in the process of unfolding substrate

    Zev A Ripstein et al.
    The structure of a substrate-engaged AAA+ unfoldase suggests a model for processive unfolding that is supported by biochemical data.
    1. Chromosomes and Gene Expression

    The dynamic assembly of distinct RNA polymerase I complexes modulates rDNA transcription

    Eva Torreira et al.
    Live-cell imaging, genetic analysis and electron cryomicroscopy identify structural motifs involved in the differential assembly of Pol I-Rrn3 complexes and Pol I homodimers in response to nutrient availability.
    1. Structural Biology and Molecular Biophysics

    The near-atomic cryoEM structure of a flexible filamentous plant virus shows homology of its coat protein with nucleoproteins of animal viruses

    Xabier Agirrezabala et al.
    The high-resolution structure of a filamentous flexible plant virus shows that there is structural homology between its coat protein and the nucleoproteins of an unrelated group of enveloped RNA animal viruses.
    1. Biochemistry and Chemical Biology

    The human coronavirus HCoV-229E S-protein structure and receptor binding

    Zhijie Li et al.
    The HCoV-229E coronavirus S-protein accommodates extensive mutational change and possesses hydrophilic subunit interfaces in the S2 region, features that provide new insights into immune evasion, cross-species transmission and membrane fusion.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure and conformational states of the bovine mitochondrial ATP synthase by cryo-EM

    Anna Zhou et al.
    Structural analysis of the ATP synthase – in combination with evolutionary covariance analysis – reveals the fold of the a subunit and shows that the enzyme can adopt several different conformations, which support the Brownian ratchet model for generating rotation.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Architecture of the ring formed by the tubulin homologue FtsZ in bacterial cell division

    Piotr Szwedziak et al.
    The architecture of the bacterial cytokinetic ring in cells and in artificial liposome reconstitutions has been described using electron microscopy, leading to a mechanism of constriction.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the lysosomal chloride-proton exchanger CLC-7 in complex with OSTM1

    Marina Schrecker et al.
    Single-particle cryo-EM structures of CLC-7 in the presence and absence of its β-subunit, OSTM1, reveal insights into transporter regulation.

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