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    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Single-particle cryo-EM structure of a voltage-activated potassium channel in lipid nanodiscs

    Doreen Matthies et al.
    The structure of a voltage-activated potassium channel in lipid nanodiscs solved using cryo-electron microscopy is similar to previous X-ray structures, and provides insights into the mechanism of C-type inactivation.
    1. Structural Biology and Molecular Biophysics

    Fidaxomicin jams Mycobacterium tuberculosis RNA polymerase motions needed for initiation via RbpA contacts

    Hande Boyaci et al.
    Cryo-electron microscopy structures show how the clinically used antimicrobial fidaxomicin binds and inhibits Mycobacterium tuberculosis RNA polymerase by acting like a doorstop to jam the enzyme in an open conformation via the general transcription factor RbpA.
    1. Cell Biology
    2. Neuroscience

    Mitochondrial support of persistent presynaptic vesicle mobilization with age-dependent synaptic growth after LTP

    Heather L Smith et al.
    Three-dimensional electron microscopy (3DEM) demonstrates the dependence on presynaptic mitochondria for vesicle mobilization as dendritic spines are silently added at P15 or synapses are silently enlarged in adults after long-term potentiation.
    1. Structural Biology and Molecular Biophysics

    Structural analyses at pseudo atomic resolution of Chikungunya virus and antibodies show mechanisms of neutralization

    Siyang Sun et al.
    Electron cryo-microscopy has been used to determine the structure of Chikungunya virus-like particles and to provide new insights into their interactions with four different antibodies.
    1. Neuroscience

    Ultrastructural heterogeneity of layer 4 excitatory synaptic boutons in the adult human temporal lobe neocortex

    Rachida Yakoubi et al.
    Neocortical synapses in layer 4 of the human temporal lobe neocortex were quantitatively characterized, at the subcellular level, using high-end, high-resolution electron microscopy and 3D-volume reconstructions.
    1. Physics of Living Systems

    Assembly principles of a unique cage formed by hexameric and decameric E. coli proteins

    Hélène Malet et al.
    Cryo-electron microscopy uncovers molecular determinants of a unique symmetry mismatched macromolecular cage in E. coli.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structure of the gene therapy vector, adeno-associated virus with its cell receptor, AAVR

    Nancy L Meyer et al.
    Cryo-electron microscopy reveals interactions at the interface between adeno-associated virus and its cellular receptor at 2.4Å resolution.
    1. Structural Biology and Molecular Biophysics

    The complete structure of the human TFIIH core complex

    Basil J Greber et al.
    The structure of human transcription factor IIH, a critical DNA repair and transcription initiation factor, has been determined by cryo-electron microscopy.
    1. Neuroscience

    Connectomics of the zebrafish's lateral-line neuromast reveals wiring and miswiring in a simple microcircuit

    Eliot Dow et al.
    The technique of serial blockface scanning electron microscopy, which permits the complete reconstruction of neuronal structures, allows comparison of the detailed "wiring diagrams" of lateral-line receptor organs in wild-type and mutant zebrafish.
    1. Structural Biology and Molecular Biophysics

    Electron cryo-microscopy structure of the canonical TRPC4 ion channel

    Deivanayagabarathy Vinayagam et al.
    Structural insights into the architecture and functional properties of zebrafish TRPC4 are revealed by high-resolution cryo-EM.