3,663 results found
  1. September 2014

    Episode 14: September 2014

    In this episode we hear about the spread of the ebola virus, the financial costs of research misconduct, aging in yeast, grooming in flies, and symbiosis between bacteria and fungal cells.
  2. Working Lives: A Series of Interviews

    Edited by Emma Pewsey
    People with a PhD in the life sciences answer questions about their life and work.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease
    Tropical disease

    Tropical Disease: A Collection of Articles

    Edited by Prabhat Jha et al.
    eLife has published papers on many tropical diseases, including malaria, Ebola, leishmaniases, Dengue and African sleeping sickness.
  3. February 2017

    Episode 36: February 2017

    In this episode we hear about epilepsy, the sushi-belt model of transport in neurons, a mother in ancient Troy, the Amazon rainforest and bias in scientific reporting.
  4. November 2013

    Episode 6: November 2013

    In this episode we hear about using electrons for protein crystallography, a receptor for carbon dioxide, arthritis, how the brain responds to a missing hand, and the best shape for whiskers.
  5. Moving On: eLife at Five

    Edited by Emma Pewsey
    To celebrate five years of eLife we catch up with some of our first authors and reflect on the current state of scientific publishing and peer review.
    1. Chromosomes and Gene Expression

    H3.3K27M mutant proteins reprogram epigenome by sequestering the PRC2 complex to poised enhancers

    Dong Fang et al.
    Redistribution of the PRC2 complex in H3.3K27M mutant cells to poised enhancers contributes to the global reduction of H3K27me3 in cells expressing the mutant proteins.
    1. Developmental Biology
    2. Evolutionary Biology

    Two consecutive microtubule-based epithelial seaming events mediate dorsal closure in the scuttle fly Megaselia abdita

    Juan Jose Fraire-Zamora et al.
    Evolutionary reduction in tissue number involves the simplification of the seaming process but not signaling during epithelial fusion.
    1. Immunology and Inflammation

    IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate

    Mark Noviski et al.
    Self-reactive B cells downregulate the IgM but not the IgD B cell receptor, and this serves as a critical tolerance mechanism because IgD is less sensitive to bona fide endogenous antigens than IgM.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Molecular mechanism to target the endosomal Mon1-Ccz1 GEF complex to the pre-autophagosomal structure

    Jieqiong Gao et al.
    The endosomal GEF Mon1-Ccz1 binds to Atg8 on autophagosomes, and recruits its substrate, the Rab7-like Ypt7, which then mediates fusion of the autophagosomes with the lysosome.

Refine your results by:

Type
Research categories