1,211 results found
    1. Neuroscience

    Optical electrophysiology for probing function and pharmacology of voltage-gated ion channels

    Hongkang Zhang et al.
    Optogenetic tools enable sophisticated measurements of a voltage-gated sodium channel implicated in pain, as well as high-throughput screening of candidate channel blockers.
    1. Neuroscience

    Encoding and control of orientation to airflow by a set of Drosophila fan-shaped body neurons

    Timothy A Currier et al.
    Electrophysiology identifies a population of fan-shaped body neurons that encode airflow in two directions relative to the fly midline and whose silencing disrupts proper orientation to airflow.
    1. Structural Biology and Molecular Biophysics

    Structure and physiological function of the human KCNQ1 channel voltage sensor intermediate state

    Keenan C Taylor et al.
    The intermediate state conformation of the human KCNQ1 potassium channel voltage sensor domain was determined, validated, and shown to be conductive under physiological conditions.
    1. Computational and Systems Biology
    2. Neuroscience

    T2N as a new tool for robust electrophysiological modeling demonstrated for mature and adult-born dentate granule cells

    Marcel Beining et al.
    T2N, a novel interface between Matlab, TREES toolbox and NEURON, was used to generate compartmental models that reproduce the electrophysiology of dentate granule cells over a multitude of species, experimental conditions and developmental stages.
    1. Neuroscience

    Combining magnetoencephalography with magnetic resonance imaging enhances learning of surrogate-biomarkers

    Denis A Engemann et al.
    Predicting age jointly from multimodal brain images and electrophysiology with machine learning enhances detecting health issues and facets of cognitive decline.
    1. Structural Biology and Molecular Biophysics

    Cannabidiol interactions with voltage-gated sodium channels

    Lily Goodyer Sait et al.
    The high resolution crystal structure and electrophysiology of a sodium channel complex with cannabidiol, a drug approved for treatment of severe epilepsies, demonstrate the basis for its structural- functional effects.
    1. Neuroscience

    A genetic link between discriminative fear coding by the lateral amygdala, dopamine, and fear generalization

    Graham L Jones et al.
    Discrimination of predictive and non-predictive fear stimuli requires plasticity in the lateral amygdala that is regulated by midbrain dopamine neurons.
    1. Neuroscience

    Thalamic reticular nucleus induces fast and local modulation of arousal state

    Laura D Lewis et al.
    A neural circuit that can selectively induce sleep-like patterns in small regions of the brain demonstrates how sleep and arousal states may be controlled in local brain regions.
    1. Neuroscience

    Monkey EEG links neuronal color and motion information across species and scales

    Florian Sandhaeger et al.
    Using Monkey EEG as a bridge technology, color and motion representations in human MEG are linked to microcircuit activity in ventral stream areas.
    1. Neuroscience

    TRPC3 is a major contributor to functional heterogeneity of cerebellar Purkinje cells

    Bin Wu et al.
    Purkinje cells feature molecular heterogeneity that introduces differentiation in physiological properties between zebrin-identified cerebellar modules and thereby underlies the differential control on sensorimotor integration.

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