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512 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Electroporated recombinant proteins as tools for in vivo functional complementation, imaging and chemical biology

    Amal Alex et al.
    An electroporation-based method allows the direct delivery of recombinant proteins into mammalian cells for in vivo functional studies.
    1. Neuroscience

    Gyrification of the cerebral cortex requires FGF signaling in the mammalian brain

    Naoyuki Matsumoto et al.
    FGF signaling is crucial for gyrus formation, proliferation of outer radial glial cells and expansion of upper layers of the cerebral cortex in gyrencephalic mammals.
    1. Microbiology and Infectious Disease

    Programmed genome editing of the omega-1 ribonuclease of the blood fluke, Schistosoma mansoni

    Wannaporn Ittiprasert et al.
    Gene knock-out of the omega-1 ribonuclease of Schistosoma mansoni eggs resulted in immunologically impaired phenotype, showcasing the novel application of CRISPR/Cas9 genome editing and utility for functional genomics in schistosomes.
    1. Developmental Biology
    2. Neuroscience

    Conserved and divergent development of brainstem vestibular and auditory nuclei

    Marcela Lipovsek, Richard JT Wingate
    The development of brainstem auditory nuclei echoes the divergent evolutionary history of amniote auditory systems.
    1. Immunology and Inflammation

    A tissue-like platform for studying engineered quiescent human T-cells’ interactions with dendritic cells

    Enas Abu-Shah et al.
    The use of advanced 3D culture systems with engineered quiescent human T-cells, mimicking in vivo cellular dynamics, paves the way to a new era of much needed pre-clinical research tools.
    1. Neuroscience

    The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice

    Xiang-Chun Ju et al.
    Introducing a hominoid-specific gene into mice induces cortical folding.
    1. Cell Biology
    2. Developmental Biology

    An efficient and scalable pipeline for epitope tagging in mammalian stem cells using Cas9 ribonucleoprotein

    Pooran Singh Dewari et al.
    Biochemical tags can be easily knocked into endogenous genes in mammalian stem cells using optimised and scalable protocols that will enable annotation of protein levels, localisation and interaction partners.
    1. Neuroscience

    Physiological and pathophysiological control of synaptic GluN2B-NMDA receptors by the C-terminal domain of amyloid precursor protein

    Paula A Pousinha et al.
    The APP intracellular domain (AICD) physiologically regulates synaptic GluN2B-containing NMDA receptor current, a process that could contribute to pathological Alzheimer's disease-related synaptic failure upon increase of AICD levels in adult neurons.
    1. Neuroscience

    An optimized CRISPR/Cas9 approach for precise genome editing in neurons

    Huaqiang Fang et al.
    CRISPR/Cas9 based genomic editing for efficient endogenous protein tagging can be achieved by targeting non-coding sequences with two guides.
    1. Developmental Biology

    SlitC-PlexinA1 mediates iterative inhibition for orderly passage of spinal commissural axons through the floor plate

    Hugo Ducuing et al.
    A combination of in vivo models and imaging techniques reveals the distribution of guidance cues and their mechanisms of action during commissural axon navigation of intermediate target.

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